摘要
目的 观察病程 2 4wk STZ-糖尿病大鼠视网膜微血管超微结构的病理改变及非酶糖化仰制剂 -氨基胍对超微结构改变的影响。方法 制备 STZ-糖尿病大鼠动物模型 ,随机分为氨基胍 (AG)组、糖尿病 (DM)组各 6只。设正常对照组 6只。 2 4wk时处死 ,取大鼠视网膜进行电镜观察。结果 DM组视网膜微血管内皮细胞、周细胞核异染色质聚集、靠边 ;胞质内线粒体肿胀、变性 ,胞浆消失 ;基底膜增厚 ;毛细血管壁断裂。 AG组上述损害明显轻于 DM组。结论 非酶糖化抑制剂对
Objective To observe the pathogenic changes of retinal microvascular ultrastructure in diabetic rats and the contribution of nonenzymation glycosylation. Methods Animal models of STZ diabetic rats were made and divided into diabetic mellitus(DM) group, aminoguandine(AG) group and control group. Each group had 6 rats. The rats were killed after 24 weeks. their retinas were studied by electronic microscope. Results Ultrastructure of retinal microvascular endothelial cells and pericyte were abnormal, and it was more obvious in DM group than in AG group.Conclusion Nonenzymation glycosylation inhibitor can prevent and cure the damage of retinal microvascular ultrastructure in STZ diabetic rats.
出处
《眼科新进展》
CAS
2000年第3期189-190,共2页
Recent Advances in Ophthalmology
