摘要
目的 :为进一步提高对乳腺粘膜相关淋巴瘤本质的认识 ,减少临床上的误诊误治。方法 :对 3例乳腺粘膜相关淋巴瘤的临床和病理特点、组织发生和治疗原则进行探讨。应用免疫组织化学S -P法 ,对肿瘤进行多种免疫学标记。结果 :临床上多发于中年妇女 ,初始为孤立性无痛性肿块。肿瘤组织由小裂样淋巴细胞、单核样B细胞、小淋巴细胞和浆细胞构成 ,浸润生长 ,形成淋巴上皮病变 ,浸润脂肪组织。免疫组织学染色CD4 5( +)、CD2 0 ( +)、CDw75( +)、轻链κ( +)、λ( +)、bcl- 2 ( +)、CD3( - )、CD4 5RO( - )、EMA( - )。证实肿瘤来源于B细胞。治疗以肿块切除后局部放疗和全身化疗为宜。结论 :该肿瘤可发生于正常存在MALT粘膜组织 ,也可发生在正常不存在MALT粘膜器官组织中 ,与感染和自身过度免疫反应性淋巴细胞增生有关。
Objective:To promote the recognition for malignant lymphoma of mucosaassociated lymphoid tissue(MALT) in breast and reduce the error chances of diagnosis and treatment.Methods:3 cases of primary lymphoma of MALT in breast were collected and the sections were reviewed.The immunophenotypes were recognized by immunohistochemical staining.Meanwhile,the clinical and pathological characteristics of MALT lymphoma were described and the histological origin and treatment principles were discussed.Results:The MALT lymphomas of breast commonly occur in adult women and presented with isolated and painless masses in clinic.The tumors were constituted with small cleaved nuclear lymphocytes,mononuclearcelllike Blymphocytes,small mature lymphocytes and plasmas cells and show off diffuse or nodular and aggressive growth form.The tumor cells infiltrated to lobule and adipose tissue and formed lymphoepithelia lesions.The tumor cells show CD 45 (+),CD 20 (+),CD 75 (+),Ig light chain κ(+),λ(+),bcl-2(+),CD 3(-),CD 45 RO(-)and EMA(-).The results proved the tumor cells were B cell origin.Conclusion:The tumor may occur in MALT as well as in the tissues without MALT and may be related to infection and lymph tissue hyperplasia.The immunophenotypes may help to the tumor diagnosis.
出处
《西北国防医学杂志》
CAS
2000年第2期134-136,共3页
Medical Journal of National Defending Forces in Northwest China
关键词
乳腺粘膜相关淋巴瘤
临床病理
误诊
误治
Lymphoma
Mammary gland
Mucosa-associated lymphoid tissue(MALT)
Immunohistochemistry
