摘要
目的 :观察 β -七叶皂甙钠对肢体缺血再灌注损伤的保护作用。 方法 :用兔造成肢体缺血再灌注损伤动物模型。实验分对照组、缺血再灌注组和β -七叶皂甙钠组。取血浆测定丙二醛、肌酸磷酸激酶、谷草转氨酶和乳酸脱氢酶含量。取骨骼肌标本测定丙二醛、髓过氧化酶活性、肌细胞线粒体钙含量和组织湿 /干重比值。结果 :缺血再灌注组与对照组比较 ,血浆和骨骼肌各项生化指标显著增高 (P <0 .0 1) ;使用 β -七叶皂甙钠后 ,血浆及骨骼肌各项测定指标较缺血再灌注组相比明显降低 (P<0 .0 5 ,P <0 .0 1)。结论 :β -七叶皂甙钠可减轻肢体缺血再灌注损伤 。
Objective:To observe the protective effects of β-aescin on ischemia and reperfusion injury of limbsMethods:Experimental models of ischemia and reperfusion injury of limb were established in 30 rabbits and were divided into control group,ischemia and reperfusion group and β-aescin group.MDA、CPK、GOT and LDH levels in plasma and MDA、MPO、mitochondia calcium and wet/dry of skeletal muscle were measured.Results:The biochemical indexes of plasma and skeletal muscle were dramatically higher than those of control group (P<0.01),while indexes on β-aescin group were significantly lower as compared with those of ischemia and reperfusion group (P<0.01,P<0.05).Conclusion:β-aescin might have a protective effect on muscular cells during ischemia and reperfusion injury of limbs.
出处
《西北国防医学杂志》
CAS
2000年第2期124-126,共3页
Medical Journal of National Defending Forces in Northwest China
