摘要
目的系统评价手法小切口无缝线白内障摘除（MSICS）与白内障超声乳化吸除术（Phaco）治疗年龄相关性白内障的疗效及安全性。方法循证医学研究。计算机检索Cochrane Library、Embase、PubMed、中国期刊全文数据库（CNKI）、中国生物医学文献数据库（CBM）、维普中文期刊数据库（VIP）。全面收集MSICS治疗年龄相关性白内障的临床随机对照试验，评价纳入研究的质量，提取有效数据，采用RevMan5．1软件进行Meta分析。结果共纳入13个临床随机对照试验，共2870眼，MSICS组1469眼，Phaco组1401眼。Meta分析显示：术后6周矫正视力≥0．3的比例两组比较差异无统计学意义怪0．61，P〉0．05），术后近期散光两组比较差异无统计学意义（Z=0．34，P〉0．05），但远期两组比较差异有统计学意义（Z=10．16，P〈0．01）。手术前后角膜内皮细胞丢失（Z=0．78，P〉0．05）及术后并发症（Z=0．74，P〉0．051比较两组差异均无统计学意义。从手术成本及手术时间看，Phaco比MSICS所需费用高且耗时长。结论MSICS治疗年龄相关性白内障与Phaco比较具有相似的疗效及安全性，但前者在手术成本、耗费时间方面有优势，有利于在没有开展超声乳化术的区域及大量基层白内障复明手术中开展。
Objective To evaluate the efficacy and safety in the treatment of age-related cataract by comparing manual small incision sutureless cataract surgery （MSICS） with phacoemulsification （Phaco）. Methods In a systematic review and meta-analysis, trials were identified by searching databases for randomized clinically controlled trials on the treatment of age-related cataract by manual small incision sutureless cataract surgery and phacoemulsification. The following databases were searched up to February 2012： Cochrane Library, Embase, PubMed, CBM, CNKI and VIP. The quality of the included trials was assessed and meta-analyses were performed with RevMan 5.1 software. Results A total of 13 randomized clinically controlled trials involving 2870 eyes were included. There were no statistically significant differences in the ratio of postoperative visual acuity ≥0.3 （Z=0.61, P〉0.05）, endothelial cell loss （Z=0.78, P〉0.05）, or postoperative complications （Z=0.74, P〉0.05）. But there were statistically significant differences in postoperative astigmatism between the two groups 6 weeks after surgery （Z=10.16, P〈0.01）. MSICS was far more economical and time saving than phacoemulsification. Conclusion Meta-analysis shows that MSICS has equal efficacy and safety compared to Phaco in the treatment of age-related cataract. Because MSICS is far more economical and time saving, it should be recommended for use in basic hospitals in China.
出处
《中华眼视光学与视觉科学杂志》
CAS
2012年第12期757-760,共4页
Chinese Journal Of Optometry Ophthalmology And Visual Science
