摘要
P21活化激酶(P21-activated kinases,PAK)参与多种重要的细胞生命活动,如细胞骨架重构、细胞迁移、细胞周期调控以及细胞的凋亡或生存。在神经系统中,PAK可能与大脑发育、神经细胞分化、突触可塑性调节等生理过程有密切关系。PAK的异常会导致诸如肿瘤、帕金森病(Parkinson’s disease,PD)、阿尔茨海默病(Alzheimer’s disease,AD)、神经发育迟缓等疾病。因此,研究PAK在神经系统中的功能具有十分重要的生理学意义。本文对这一蛋白激酶家族在神经系统中的生物学功能及其机制的研究进展作一综述。
P21-activated kinases （PAK） participate in a variety of important cellular activities, such as cytoskeleton remodeling, cell migration, cell cycle regulation, and apoptosis or survival. PAK also has an important impact on brain development, neuronal differentiation, and regulation of synaptic plasticity in the nervous system. PAK abnormalities result in diseases including cancer, Parkinson’s disease （PD）, Alzheimer’s disease （AD） and neural retardation. Therefore, it is of vital physiological significance to investigate the neuronal function of PAK. In this paper we review the advancement of research on the neuronal biological function and the underlying mechanisms of PAK.
出处
《生理学报》
CAS
CSCD
北大核心
2012年第6期700-706,共7页
Acta Physiologica Sinica
基金
supported by the National Natural Science Foundation of China (No.81000535)
the Natural Science Foundation of Zhejiang Province
China (No.Y2100508)
关键词
P21活化激酶
神经系统
疾病
P21-activated kinases
nervous system
diseases
