摘要
目的探讨儿童系统性红斑狼疮(SLE)的临床特点。方法对127例儿童SLE和120例成人SLE首次住院病史进行回顾性分析。从性别、临床表现、实验室检查及肾脏病理等方面,比较儿童与成人SLE特点。结果儿童SLE男女比例1:6.1,成人SLE男女比例1∶5,两组性别构成比差异无统计学意义;儿童SLE患者发病初的平均疾病活动度指数(SLEDAI)明显高于成人,差异有统计学意义(Z=4.15,P<0.000);儿童SLE患者平均累及器官数多于成人,差异有统计学意义(Z=6.30,P<0.000)。儿童SLE肾脏病理类型依次为Ⅳ型57.1%、Ⅲ型26.3%、Ⅴ型18.4%、Ⅲ型+Ⅴ型10.5%、Ⅳ型+Ⅴ型2.6%,成人SLE依次为Ⅳ型45.5%、Ⅴ型22.7%、Ⅲ型+Ⅴ型13.6%、Ⅱ型和Ⅲ型均为9.1%。结论儿童SLE与成人SLE相似,女性多见;儿童SLE较成人SLE疾病活动性强,累及器官多,肾脏病理改变同成人以重型多见,而无症状的肺脏病变较成人多见,应引起重视。
Objective To discuss the differences of the gender, clinical features, laboratory findings and renal pathology between children and adults with systemic lupus erythematosus （SLE）. Methods A retrospective study was performed in 127 children and 120 adults with SLE on clinical data from their first hospitalization. Results The ratio of male to female in chil dren and adult patients was 1：6.1 and 1：5, respectively. The difference of the gender ratio was not significant between the two groups. The SLE dieases active index was significantly higher in children group than that in adult group （Z=4.15, P〈0.000）. The number of involved organs was significantly higher in children group than that in adult group （Z=6.30, P〈0.000）. In chil dren group, renal pathological examinations showed grade IV （57.1%）, grade Ⅲ （26.3%）, grade V （18.4%）, grade Ⅲ＋V （10.5%） and grade IV ＋ V（2.6%）. Conclusions Children with SLE are liable to have more active disease activity and involve more organs than adult patients.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2012年第12期1132-1134,共3页
Journal of Clinical Pediatrics
关键词
系统性红斑狼疮
临床特点
儿童
systemic lupus erythematosus
clinical features
children
