摘要
目的探讨幼年特发性关节炎全身型（SOJIA）反复发作的临床特点及治疗方法。方法回顾性分析27例SOJIA的临床资料，将27例sOJIA分为2组，无反复发作者为A组，反复发作者为B组，以激素和甲氨喋呤（MTX）联合治疗作为基本方案。随访1年以上。结果治疗前，B组患儿的浆膜腔积液发生率（100％）明显高于A组（33．3％），差异有统计学意义（P〈0．05）。治疗前和治疗3周时，B组患儿的外周血IgM、铁蛋白（SF）、NT-proBNT、CK水平均高于A组，差异均有统计学意义（f=2．83-7．23，P均〈O．05）。两组患）LMTX应用率和遵照激素联合MTX治疗的减量、停药原则的人数比例A组均高于B组，差异有统计学意义（P〈O．05）。结论浆膜腔积液，血液IgM、SF、NT-proBNT、CK水平异常升高，单用激素治疗，联合用药疗程不足可能是SOJIA反复发作的原因。
Objective To investigate the clinical features and treatments of children＇s recurrent systemic onset juvenile idiopathic arthritis （SOJIA）. Methods To retrospective analysis of the clinical data of 27 cases of children with SOJIA, which were divided into two groups. The non-recurrent SOJIA children were referred to as A group, and the recurrent SOJIA chil- dren were referred to as B group. The therapy of hormones in combination with methotrexate （MTX） was as the basic program. Follow up of A and B group more than 1 year. Results Before treatment, the incidence of serous effusion B group （100%） was significantly higher than A group （33.3%）, the difference of the two groups was statistically significant （P〈0.05）. Before treat- ment and after 3 weeks treatment, among the laboratory parameters of IgM, SF, NT-pro BNT, CK of A, B groups were statisti- cally significant （P〈0.05）; the difference orb groups were significantly higher than A group （t=2.83-7.23, AIIP〈0.05）. The ap- plication rate of MTX, the proportion of following of the principle of the withdrawal and reduction of hormones and MTX were statistically significant （BothP〈0.05）. Conclusions Serous effusion, the high levels of IgM, SF, NT-proBNT、 CK of peripheral blood, use of hormones alone, and too short treatment of combation drugs may be the reason of the recurrent attacks of SOJIA.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2012年第12期1128-1131,共4页
Journal of Clinical Pediatrics
关键词
全身型幼年特发性关节炎
临床特点
治疗
疗效
systemic onset juvenile idiopathic arthritis
clinical features
treatment
clinical efficacy
