摘要
目的 检测食管癌放疗前后 DNA含量的改变及其对预后的影响 ,并评价食管癌治疗后生存率。方法 对 5 2例可根治的胸中段食管鳞状细胞癌行术前放疗 ,并行根治性切除术。两野对穿照射 ,肿瘤剂量 30～ 40 Gy/15～ 2 0次 ,3～ 4周 ,ICM分析 DNA倍体和 DNA含量。结果 放疗前、后异倍体率分别为 89.4%和 76 .7% ;放疗后DNA倍体和 DNA含量对预后均有明显影响 (P=0 .0 1) ;放疗使 DAN含量明显下降 (P=0 .0 0 2 ) ,而 DNA倍体变化不明显 (P=0 .2 0 83)。结论 活检标本 DNA含量检测对评估预后的价值可能不大 ,手术标本 DNA含量能够明确地预示生存率 ,放疗引起 DNA含量显著下降 ,而对倍体的影响不明显。
Objective To study the value of DNA content in prognosis of esophageal carcinoma with preoperative radiotherapy.Methods From Nov.1979 to Dec.1996,52 patients were treated by radical esophagectomy plus preoperative radiotherapy in our hospital.All were confirmed as squamous cell carcinoma.Two vertical irradiation fields were used to deliver a total dose of 30～40 Gy/15～20 F/3～4 W.Sections were stained with Feulgen technique and the DNA ploidy and DNA content were analyzed with ICM.Results The aneuploidy rates wrer 89.4% and 76.7% for pre and post radiation specimens,respectively ( P = 0.2083 ).DNA content significantly decreased after radiation ( P =0.002).Conclusion DNA content of the surgical specimens had influence on the prognosis of esophageal carcinoma,radiotherapy may cause DNA content down.
出处
《实用肿瘤杂志》
CAS
北大核心
2000年第3期160-162,共3页
Journal of Practical Oncology
