摘要
目的：探讨胃间质瘤（ｇａｓｔｒｉｃ ｓｔｒｏｍａｌ ｔｕｍｏｒ，ＧＳＴ）的组织发生、组织分型及预后关系。方法：结合临床病理特点与免疫组化ＣＤ３４、Ｓ－１００蛋白、ＳＭＡ标记对６０例ＧＳＴ进行观察。结果：ＧＳＴ良、恶性与肿瘤大小。核分裂像多少、细胞异型性、细胞密度、肿瘤组织浸润相关（Ｐ＜０.０５），而与肿瘤出血、坏死无关（Ｐ>０.０５）；ＣＤ４、Ｓ－１００蛋白、ＳＭＡ阳性率与肿瘤分化程度、转移生存率相关（Ｐ＜０.０５）。Ｓ－１００蛋白、ＳＭＡ阳性率越低，肿瘤恶性程度越高，越易发生转移，生存率越低，ＣＤ３４则相反。结论： ＣＤ３４、ＳＭＡ和 Ｓ－１００蛋白表达可为 ＧＳＴ预后提供有价值参考。
Objective: To investigate the relationship between the histogenesis, the histological type and the prognosis in the gastric stromal tumors (GST). Methods: The clinicopathologic features and immunohistochemical expressions of CD34, S-100 protein and smooth muscle actin (SMA) were detected in 60 cases of GST. Results: There were significant differences between the benign and malignant GST cases in tumor size, mitosis, atypism, cellulary and invasion (P < 0. 05), but were not in bleeding and necrosis (P > 0. 05 ). The positive rates of CD34, S-100 protein and SMA were closely related with the metastasis, survival rate and tumor differentiation (P < 0. 05). The lower the positive rates if S-100 protein and SMA and the more malignant of the tumors, the easier the metastasis of the tumors and the lower the survival rates, while in contrary for CD34. Conclusion: The CD34,S-100 protein and SMA expressions can provide useful information for the prognosis of GST patients.
出处
《癌症》
SCIE
CAS
CSCD
北大核心
2000年第6期579-581,共3页
Chinese Journal of Cancer
