摘要
微小RNA（microRNA，miRNA）在生物体的发育生长、细胞增殖分化及凋亡、激素的分泌和肿瘤发生等领域中具有重要的调控功能。哺乳动物中枢神经系统的发育过程需要经历多个位点的神经管闭合，若神经管闭合失败或早闭，会导致神经管缺陷（neural tube defects，NTD）的发生，这是一种严重的、多因素的先天性复杂疾病，以往文献报道有多种miRNAs参与了NTD的发病机制。
MicroRNAs （miRNAs） are known to play an important role in regulating the cell proliferation, dif- ferentiation and organogenesis. Abnormal expression of miRNAs is associated with increased risk for various diseases, such as neural tube defects （ NTD）, which is a severe developmental disease as the result of closing the neural tube incompletely or too early. The present review summarizes some enriched miRNAs in the brain of mammals and their spatial temporal fea- ture, and tries to elaborate the relationship between the aberrant expression of miRNAs and the pathogenesis of NTD.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2012年第12期2291-2296,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.31071133)
北京市科委科技新星资助项目(No.2010B045)
