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葡萄糖调节蛋白78在肝癌中的研究进展 被引量：4

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摘要 葡萄糖调节蛋白78(GRP78)是内质网应激(ERS)相关的重要分子伴侣,在机体正常肝脏组织中几乎不表达,而在肝癌组织中呈高表达状态,这有利于肝癌的增殖及耐药性的产生,并影响肝癌的侵袭与转移。因此,以GRP78为靶点的基因干扰技术,有望成为肝癌基因治疗的新途径。
作者 代景友 韩卓越 王书 张新晨
机构地区 哈尔滨医科大学第二附属医院普通外科
出处 《中国现代普通外科进展》 CAS 2012年第11期886-888,910,共4页 Chinese Journal of Current Advances in General Surgery
基金 黑龙江省自然科学基金资助项目(D200933)
关键词 葡萄糖调节蛋白78 内质网应激 肝肿瘤
分类号 R979.1 [医药卫生—药品]
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参考文献1

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共引文献61

同被引文献44

  • 1Craig C Mello, Darryl Conte Jr.Revealing the world of RNA interference[J].Nature, 2004, 431:338-342.
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引证文献4

二级引证文献5

中国现代普通外科进展
2012年 第11期

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