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受体酪氨酸激酶EphA2在肾细胞癌发生及发展中的作用 被引量：3

EphA2 in the occurrence and development of renal cell carcinoma
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摘要 Eph(Erythropoietin producing hepatocellular carcinoma)基因家族属于受体酪氨酸激酶(receptor tyrosine kinases,RTKs)家族中最大的一个亚族,可分为EphA和EphB。Eph基因家族参与很多生理活动,同时Eph基因的过表达也可导致细胞的恶性转化。近年来,研究发现EphA2基因的表达与肾细胞癌的分级、淋巴结转移、无瘤生存期等都直接相关,也与肾细胞癌的发生、发展和预后有关。为此,EphA2基因可能成为诊断、预测肾细胞癌的恶性程度及判断预后的生物学标记物,为肾细胞癌的生物治疗提供新靶点和新思路。 The largest subfamily of the tyrosine kinase receptor of Eph could be divided into two groups, EphA and EphB. Ephs play an important role in many physiological activities, and their overexpression may lead to malignant transformation of ceils. In recent years, the expression of EphA2 has been found to be directly related to the carcinoma grade, lymph node metastasis and disease- free interval, as well as to the occurrence, progression and prognosis of renal cell carcinoma. Therefore, EphA2 may become biological markers for the diagnosis, malignancy assessment, and prognosis of renal cell carcinoma, and providing a new target and new concep- tions for the biological treatment of renal cancer.
作者 郭庆 王建东 石群立
机构地区 南京大学医学院临床学院(南京军区南京总医院)病理科
出处 《医学研究生学报》 CAS 北大核心 2012年第12期1333-1336,共4页 Journal of Medical Postgraduates
关键词 EPHA2 肾细胞癌 受体酪氨酸蛋白激酶 EphA2 Renal cell carcinoma Receptor tyrosine kinases
分类号 R737.11 [医药卫生—肿瘤]
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参考文献25

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二级参考文献30

共引文献35

同被引文献57

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引证文献3

二级引证文献12

医学研究生学报
2012年 第12期

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