摘要
Napsin A是一种天门冬氨酸蛋白酶，主要表达于肺和肾脏的上皮细胞中。研究发现，在肺部肿瘤中，Napsin A主要在肺腺癌中表达。在。肾脏肿瘤中，Napsin A主要表达在肾细胞癌，尤其是乳头样和透明样肾细胞癌。鉴于此，Napsin A在肺腺癌和肾细胞癌的诊断及鉴别诊断中起到重要作用。本文就近年来关于Napsin A在肿瘤中作用的研究进展作一综述。
Napsin A is one kind of aspartic protease present in the epithelial cells of the lung and kidney. Recent studies have shown that, in lung tumors, napsln A expression is restricted to lung adenocarcinomas, whereas among renal tumors, it is mainly expressed in renal cell carcinomas, especially the papillary and clear cell subtypes. In view of its restricted expression, napsin A plays an important role in the diagnosis and differential diagnosis of both lung adenocarcinoma and renal cell carcinoma. In the current review, we summarize the most recent data on napsin A and its relationship with cancer.
出处
《国际呼吸杂志》
2012年第24期1894-1897,共4页
International Journal of Respiration
