摘要
目的:研究慢性乙型肝炎患者HBV标志物模式(HBV-M)、病毒载量(HBV-DNA)的关系。方法:运用酶联免疫吸附测定法(ELISA)、荧光定量聚合酶链反应(FQ-PCR)技术对296例慢性乙型肝炎患者检测血清标志物(HBV-M)及HBV-DNA载量进行统计学分析。结果:296例慢性乙型肝炎患者中,HBV-DNA阳性率为85.5%,HBV-DNA平均载量为2.973×108copy/ml;七组HBV-DNA阳性率差异有统计学意义(P<0.05),以A组(大三阳组)检出率(98.1%)为最高,与其他组比较,差异有统计学意义(P<0.05);慢乙肝轻、中、重三组中以中度检出率(92.6%)为最高,且与其他两组相比,差异有统计学意义(P<0.01);HbeAg阳性组检出率高于HbeAg阴性组,差异有统计学意义(P<0.01)。结论:临床上针对慢性乙型病毒性肝炎患者,需将HBV-M标志物模式与HBV-DNA载量联合检测。
Objective：To study the relationship of the patients with chronic hepatitis B markers model （ HBV-M ） and viral load （ HBV-DNA ） . Method：HBV-M and HBV-DNA in 296 hepatitis B patients were determined using enzyme-linked immunosorbent assay （ ELISA ） and fluorescence quantitative polymerasc chain reaction （ FQ-PCR ） . The SPSS17.0 statistical software was used for statistical analysis. Result：In 296 eases： the positive rate of HBV-DNA was 85.5%, HBV-DNA of average load is 2.973E＋08copy/ml, HBV-M group A detection rate of 98.1% was the highest. In 3 groups：light, moderate,heavy, moderate detection rate was 92.6% and was the highest, Compared with the other two groups have significant difference. The detection rate of HBeAg＋ group was higher than that of HBeAg-, and the difference was statistically significant. Conclusion：To detect the markers of HBV-M mode and HBV-DNA load of patients with chronic viral hepatitis B is very important.
出处
《中国医学创新》
CAS
2012年第35期116-117,共2页
Medical Innovation of China
