摘要
目的:探讨血清骨保护素(OPG)水平与冠状动脉钙化(Coronary artery calcification,CAC)的相关性。方法:入选50例患者,所有入选患者均冠状动脉16层螺旋CT扫描,根据结果,CAC的患者30例作为实验组,冠脉无钙化者20例作为对照组,在入院24小时内记录各组患者的一般资料(包括性别、年龄、血脂、血糖、血压等),ELISA法检测各组患者血清OPG水平,计算CAC的积分,分析OPG与CAC的相关性。结果:(1)与对照组相比,CAC患者血清OPG均高于对照组,差异有统计学意义(P<0.01);(2)OPG水平与CAC的程度相关,且随着钙化积分的升高而升高,差异有统计学意义(P<0.01);(3)OPG与FPG及LDL水平正相关(P<0.01或P<0.05)。结论:血清OPG浓度与CAC程度密切相关,随着CAC的积分升高而升高,可能参与了CAC的发展,OPG水平与FPG、LDL水平正相关,提示其参与CAC的发展可能与血糖、血脂代谢有关,共同参与了CAC的发展。
Objective：To analyze the serum levels of osteoprotegerin in the patients with Coronary artery calcification, and to explore the relevance between above mentioned.Methods： 50 cases patients were collected in the people＇s hospital of Zhalantun, All patients were screened for carotid plaque by using 16-shce spiral CT. According to the results, patients were classed as follows：the Coronary artery calcification group （n=30）,no Coronary artery calcification group （n=20）, General data of each patient, including gender, age, blood fat and blood glucose ,blood pressure, etc, were measured within 24 hours after admission to hospital, serum OPG levels were measured, coronary artery calcification scores were counted according to the result of The 16-slice spiral CT were used to analyze mentioned of the serum levels of osteoprotegerin and Coronary artery calcification. Results： （1）Serum OPG levels were significantly higher in the Coronary artery calcification patients than the control patients （p〈0.01）; （2）The scores of CACwere positively correlated with OPG levels （p〈0.01）; （3）Fasting plasma glucose （FPG） and LDL levels were significantly higher in CAC patients than the control patients （p〈0.01, P〈0.05）.Conclusions： Serum OPG were significantly higher in CAC patients. Serum OPG levels were related with the scores of CAC, with the scores increased and OPG levels rised, this means that the marker has close relation with lesions progress of CAC. And the levels of OPG are significantly and positively correlated to FPG and LDL, which signifies in the development of CAC.
出处
《中国伤残医学》
2012年第12期21-23,共3页
Chinese Journal of Trauma and Disability Medicine
关键词
骨保护素
冠状动脉钙化
冠状动脉钙化积分
Osteoprotegerin
Coronary artery calcification
Coronary artery calcification scores
