摘要
髓样抑制性细胞（MDSC）是一组来源于未成熟髓系细胞不同分化阶段的异质性细胞群体，可通过抑制T细胞及自然杀伤（NK）细胞的活性、诱导T—regs细胞的产生、参与肿瘤血管生成等多种途径诱导免疫抑制、介导免疫耐受，在肿瘤的发展和转移方面发挥着重要的作用。运用各种方法促进MDSC分化成熟，减少其数量、抑制其功能等可能有助于肿瘤患者正常免疫状态的恢复，控制肿瘤的进展，提高其他抗肿瘤治疗的疗效。靶向MDSC已成为肿瘤免疫治疗的新思路。
Myeloid-derived suppressor cells （MDSCs） are a heterogeneous population of immature myeloid ceils at different stages of maturation. MDSCs mediate the suppression of the anti-tumor immunity,and play a crucial role in cancer tolerance through suppressing the activity of T cells and natural killer cells, indu- cing T-regs and involving the angiogenesis, and then contribute to the tumor development and metastasis. Pro- moting the differentiation of MDSCs, reducing its quantity and inhibiting its function by using various methods may contribute to the recovery of patients normal immune status, the tumor progression control, and improve- ment of the efficacy of other anti-neoplastic therapies. Therefore,possible novel therapeutic approaches targeted at MDSCs could be considered and developed rapidly now.
出处
《国际肿瘤学杂志》
CAS
2012年第12期898-902,共5页
Journal of International Oncology
关键词
髓系细胞
免疫耐受
免疫疗法
Myeloid cells
Immune tolerance
Immunotherapy
