摘要
Runt相关转录因子2（Runx2）是多瘤病毒增强子结合蛋白2／核心结合因子（PEBP2／CBF）转录因子家族的成员，可以调节基质金属蛋白酶（MMP）、骨桥蛋白（OPN）和骨涎蛋白（BSP）等肿瘤转移相关蛋白的表达。在乳腺癌、前列腺癌等肿瘤中，Runx2表达明显上调，并且其异常表达与细胞转化和肿瘤进展密切相关。研究表明，Runx2与恶性肿瘤中一些通路的活化密切相关，而这些通路的激活又是启动恶性肿瘤转移的关键步骤。针对Runx2的靶向治疗有可能为阻断肿瘤的转移提供新的治疗选择。
Runt-related transcription factor 2 （Runx2） is a nuclear transcription factor of PEBP2/CBF superfamilies, and can regulate matrix metalloproteinase （MMP）, osteopontin （OPN） and bone sialoprotein （BSP） which are associated with the metastasis of tumors inchlding breast cancer and prostate cancer. In these cancers, the expression of Runx2 is highly up-regulated, which is closely correlated with the cell transformation and tumor progress. Lots of studies have demonstrated that the function of Runx2 is involved in several signal pathways activation, which can promote the early metastasis of malignant tumors. Therefore,the treatment targe- ting to Runx2 may be a new clinically choice to block the metastasis of tumors in the future.
出处
《国际肿瘤学杂志》
CAS
2012年第12期892-894,共3页
Journal of International Oncology
基金
国家自然科学基金资助项目（81001186）
天津市自然科学基金资助项目（10JCYBJC14100、11JCZDJC28000）
