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真核生物酸性核糖体P蛋白的结构和功能 被引量：3

The structure and function of acidic ribosomal P proteins
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摘要 真核生物酸性核糖体P蛋白位于60S大亚基上。酸性核糖体P蛋白是多功能蛋白:P0对于60S大亚基的组装起着关键性作用;P1和P2在细胞增殖、细胞凋亡、肿瘤及免疫性疾病发生等方面发挥着重要功能,而且它们在蛋白质翻译等生命活动中也起着调节作用。本文就真核生物酸性核糖体P蛋白的结构和功能做简要综述。 The acidic ribosomal P proteins,which consist of P0、P1、P2,are present in the 60S ribosomal subunits of all eukaryotic cells.The acidic ribosomal P proteins are multifunctional proteins： P0 is important for assembling large 60S subunit;P1 and P2 proteins are involved in cell proliferation,apoptosis,tumor and immunological diseases.Furthermore,there is also evidence that P proteins play a role in protein synthesis.This review focuses on the structure and function of these three acidic ribosomal proteins.
作者 肖瑞琳 胡苗清 柴宝峰 梁爱华
机构地区 山西大学生物技术研究所化学生物学与分子工程教育部重点实验室
出处 《生命的化学》 CAS CSCD 2012年第6期546-549,共4页 Chemistry of Life
基金 国家自然科学基金项目(31071294) 山西省自然科学基金项目(2010011040-1)资助
关键词 真核生物酸性核糖体P蛋白 结构 功能 ribosomal P proteins structure function
分类号 Q51 [生物学—生物化学]
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共引文献4

同被引文献32

  • 1吴海燕,唐圣松.酸性核糖体磷酸化蛋白P(0-2)的研究进展[J].南华大学学报（医学版）,2006,34(5):634-637. 被引量：5
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生命的化学
2012年 第6期

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