摘要
目的探讨辛伐他汀联合阿魏酸钠治疗早期糖尿病肾病(DN)的疗效。方法将46例早期DN患者随机分成试验组和对照组,对照组在常规治疗基础上给予辛伐他汀20 mg/次,1次/晚;试验组在对照组基础上给予阿魏酸钠注射液0.3 g/次,静脉滴注,1次/d。2组均治疗4周。观察治疗过程中的不良反应,比较24 h尿微量白蛋白(UAER)、血尿素氮(BUN)、肌酐(Scr)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、平均动脉压(MAP)水平的变化情况。结果 2组治疗后UAER、BUN、Scr、TC、TG、LDL及MAP均较治疗前明显降低,差异具有统计学意义(P<0.05或P<0.01)。试验组UAER、BUN、Scr、TC及MAP的下降程度比对照组明显,差异有统计学意义(P<0.05或P<0.01)。结论使用辛伐他汀联合阿魏酸钠治疗早期DN的调脂作用明显,可有效保护肾功能,是一种安全有效的延缓DN发展的治疗方法。
Objective To explore the effect of simvastatin associated with sodium ferulate on treatment for early diabetic nephropathy （DN）. Methods 46 early DIN patients were randomly divided into 2 groups. Apart from the conventional therapy, the control group received simvastatin 20 mg/d for 1 time per evening, while the experiment group received simvastatin（same use as control group） plus sodium ferulate 0.3 g/d by venous infusion. Treatment lasted 4 weeks in both groups. UAER, BUN, Scr, TC, TG, LDL and MAP were detected before and after treatment, and the adverse reactions were observed. Results After the treatment, the levels of UAER, BUN, Scr, TC, TG, LDL and MAP reduced significantly in both groups （P〈0.05 or P〈0.01）. Compared with the control group, the levels of UAER, BUN, Sc, TC and MAP in the experiment group reduced obviously, and there were significant differences （P 〈 0.05 or P 〈 0.01 ）. Conclusion Simvastatin associated with sodium ferulate regimen for treatment of early DN can effectively protect the renal function. It is a safe and effective way to defer the progress of diabetic nephropathy.
出处
《实用临床医药杂志》
CAS
2012年第23期115-116,共2页
Journal of Clinical Medicine in Practice
关键词
辛伐他汀
阿魏酸钠
早期糖尿病肾病
Simvastatin
sodium ferulate
early diabetic nephropathy
