摘要
目的探讨江苏地区508例肾活检资料的流行病学特点及病理类型与免疫荧光之间的关系。方法回顾性分析508例因肾脏疾病而行肾活检患者的临床资料。结果 508例患者年龄(36.1±13.6)岁;男242例,女266例。狼疮性肾炎(LN)、肾小管-间质疾病(TID)、膜增生性肾小球肾炎(MPGN)、新月体性肾炎(CREGN)、轻微病变(MGA)及IgA肾病(IgAN)女性居多。原发性肾小球肾炎392例,继发性肾小球肾炎109例。最常见病理类型为IgAN、系膜增生性病变(MsPL)、膜性肾病(MN)、MGA、微小病变(MCNS)、局灶阶段性肾小球硬化症(FSGS)、LN。最常见的临床表现为肾病综合征(NS)、肾炎综合征(CNS)。NS中最常见的病理类型为MCNS、MN、MsPL、IgAN、FSGS、MGA;CNS最常见的病理类型为:IgAN、MsPL。IgAN肾组织以IgA沉积为主;DN肾组织83.3%有不同程度及类型的免疫球蛋白沉积;LN肾组织92.3%病例呈"满堂亮"表现。结论江苏地区肾脏疾病男女比例相当,青壮年是高发人群;最常见的肾小球疾病是IgAN;IgAN肾脏组织以IgA沉积为主;最常见的临床表现是NS;江苏北部Alport综合征发病率较其他地区高。
Objective To explore the epidemiological characteristics and relationship be- tween pathological types and immunofluorescence of 508 renal biopsy materials in Jiangsu area. Methods 508 renal biopsy materials of patients with renal disease were retrospectively analyzed. Results The average age was （36.1 ± 13.6）. 242 cases were male, 266 cases were female. The female patients were prone to suffer LN, TID, MPGN, CREGN and IgAN. 392 cases were prima- ry glomerulonephritis, and 109 cases were secondary glomerulonephritis. The most common patho- logical types were IgAN, MsPL, MN, MGA, MCNS, FSGS and LN. The most common dinical manifestations were NS, CNS. The most common pathological types in NS were MCNS, MN, MsPL, IgAN, FSGS and MGA. The most common pathological types in CNS were IgAN and MsPL. IgA deposition was expressed as the main manifestation in IgAN kidney tissues, 83.3 % of DN kidney tissues had different degree and type of immune globulin deposition, and 92.3 % of LN renal tissues showed ＂a bunch light＂ performance. Conclusion In Jiangsu area, there is a similar proportion of kidney disease in male and female, young and middle - aged patients are high - risk groups. The most common glomerular disease is IgAN. The most common clinical manifestation is NS. The morbidity of Alport syndrome in northern Jiangsu is higher than other areas.
出处
《实用临床医药杂志》
CAS
2012年第23期59-61,共3页
Journal of Clinical Medicine in Practice
关键词
肾活检
流行病学
病理类型
renal biopsy
epidemiology
pathological type
