摘要
目的探讨正电子发射断层扫描/计算机断层扫描(PET/CT)在鼻咽癌诊断及治疗后随访中的应用价值。方法对本院接受PET/CT全身显像的62例鼻咽癌和14例鼻咽部炎症患者病例资料进行回顾性分析。鼻咽癌初诊患者16例,治疗后患者46例。检查在治疗前或治疗结束6周后进行。最终诊断由病理活检和临床随访确定,随访时间>6个月。结果①以鼻咽部黏膜非对称性增厚或形成软组织肿块及结节,同时局部FDG代谢活跃或异常活跃为判断标准诊断鼻咽癌,PET/CT诊断鼻咽癌的敏感性、特异性、准确性分别为93.8%、92.9.%、93.3%。②治疗后组CT表现形态学异常24例,PET显示代谢增高13例。最终确定为肿瘤残留复发8例。CT检查阴性患者22例,PET显示高摄取2例,其中1例确诊为肿瘤残留。经病理诊断及随访确定局部无肿瘤残留复发病灶者37例。③43.8%的患者发现了颈部淋巴结转移灶,19.4%的患者发现有远隔转移。结论 18F-FDG PET/CT不仅在鼻咽癌诊断上有重要价值,在肿瘤疗效评价和分期与再分期上有更明显的优势。
Objective To investigate the clinical value of 18-FDG PET/CT imaging in the diagnosis and treatment of nasopharygeal carcinoma （NPC）. Methods Sixty-two patients with na- sopharygeal carcinoma underwent 18-FDG PET/CT examination. Sixteen of them received their first time examination and 46 had previous treatment. Another 14 patients with nasopharygeal inflammation were taken as control group. The examination was conducted before treatment or 6 weeks after treatment. The final diagnosis was determined by the results of pathological tests and the random follow-up. The follow-up was longer than 6 months. Results ①When nodular or massive hyper- metabolism area in nasopharynx was detected in PET, the soft tissue mass or thickening was also detected in the same region in CT. The diagnostic sensitivity, specificity and accuracy of PET/CT in NPC were 93.8%, 92.9. % and 93.3%. ② For treated patients, 13 of 24 cases that were posi- tive in CT showed hypermetabolism in PET. Among them, 8 cases were finally diagnosed as neo- plasm residue/recurrence. Two of 22 patients without changing in CT show positive in PET, 1 was diagnosed as neoplasm residue. ③Regional nodal involvement were detected in 43.8 % and distant metastases to bone, lungs, liver and brain in 19.4%. Conclusion 18F-FDG PET/CT is a useful modality for diagnosis and staging of NPC and has the potential to detect the neoplasm residual/re- current.
出处
《实用临床医药杂志》
CAS
2012年第22期27-29,共3页
Journal of Clinical Medicine in Practice
