摘要
目的探讨联合检测类风湿因子(RF)、抗角蛋白抗体(AKA)、C反应蛋白(CRP)和抗环瓜氨酸肽(抗-CCP)抗体诊断类风湿关节炎(RA)的临床意义。方法检测72例RA患者和73例其他风湿类疾病患者的RF、AKA和CRP以及抗-CCP抗体。结果 72例患者血清中,RF灵敏度和特异性分别为64.8%和75.6%,AKA灵敏度和特异性分别为73.5%和94.7%,CRP灵敏度和特异性分别为85.2%和34.7%,抗-CCP抗体灵敏度和特异性分别为75.6%和92.8%,4项联合检测灵敏度和特异性分别为98.7%和93.8%。结论 RF、AKA、CRP和抗-CCP抗体4项指标联合检测可明显提高诊断RA的敏感性,有助于RA的诊断。
Objective To evaluate the diagnostic value of combined determination of serum rheumatoid factor（RF）, antikeratin antibody（AKA） c-reaction protein（CRP） and anti-cyclic citrulline peptide（anti-CCP） anti-body in patients with rheumatoid arthritis（RA）. Methods All the level of RF, AKA, CRP and anti-CCP were determined in 72 patients with RA and in 73 patients with other rheumatic diseases. Results The diagnostic sensitivity of RF, AKA, CRP and anti-CCP were 64.8 %, 73.5 %, 85.2 % and 75.6 %, respectively, and the specificity were 75.6 %, 94. 7 %, 34.7 % and 92.8 %, respectively. The specificity was 92.8 % and the sensitivity was 98.7 % with combined determination of RF, CRP and anti-CCP. Conclusion The combination of RF, AKA, CRP and anti-CCP may offer clinical benefits for diagnosis of RA and can significantly improve the sensitivity to diagnose RA.
出处
《实用临床医药杂志》
CAS
2012年第21期124-125,128,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220162)
关键词
类风湿关节炎
类风湿因子
C反应蛋白
抗环瓜氨酸肽抗体
rheumatoid arthritis
rheumatoid factor
C-reaction protein
anti-cyclic citrulline peptide antibody
