摘要
目的对比序贯疗法、四联疗法及标准三联疗法根除幽门螺杆菌(Hp)的疗效。方法选取本院门诊Hp阳性病例105例,随机分为3组,A组采用序贯疗法;B组采用四联疗法;C组采用标准三联疗法。停药4周后复查胃镜、快速尿素酶试验及14C呼气试验,观察慢性胃炎改善、溃疡愈合及Hp根除情况。结果四联疗法与序贯疗法,对Hp阳性的慢性胃炎及消化性溃疡患者的Hp根除率、慢性胃炎改善及溃疡愈合,以及Hp感染复发率方面均显示出良好的疗效,而标准三联疗法显著劣于其他2种方案。3种方案的不良反应发率均较低,且程度轻。结论含泌剂四联疗法与序贯疗法在根除Hp、改善慢性胃炎、促进溃疡愈合以及降低复发率的疗效优于标准三联疗法,且不增加不良反应发生率及程度,可作为Hp感染初治患者的首选方案。
Objective To compare the efficacy of sequential therapy, quadruple therapy and standard triple therapy for the eradication of helicobacter pylori （Hp）. Methods A total of 105 Hp positive patients were selected and randomly divided into three groups. Group A received sequential therapy, group B received quadruple therapy and Group C received standard triple therapy. Endoscopy, rapid urease test and 14C breath test were done 4 weeks after review, and the improve- ment of chronic gastritis, ulcer healing and eradication of Hp circumstances were observed. Results Quadruple therapy and sequential therapy containing secretagogues showed good efficacy （Hp eradication rates, improvement of chronic gastritis and ulcer healing, and Hp infection recurrence rate） to Hp-positive chronic gastritis and peptic ulcer patients, while standard triple therapy was significantly worse than the other two kinds of programs. Three kinds of programs hair adverse re- action rate was lower, and was not serious. Conclusion Quadruple therapy and 10 d sequential therapy containing secretagogues are more effective than standard triple therapy in the eradication of Hp, chronic gastritis. It can promote ulcer healing and reduce the relapse rate, but it does not in- crease the incidence and severity of adverse reactions, which can be used as the preferred solution to Hp infection in patients with no previous treatment.
出处
《实用临床医药杂志》
CAS
2012年第21期105-107,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220185)
关键词
序贯疗法
四联疗法
三联疗法
幽门螺杆菌
sequential therapy
quadruple therapy
triple therapy
helicobacter pylori
