摘要
目的观察冠心病心绞痛患者血清C反应蛋白(CRP)、尿酸(UA)、血脂、胆红素水平的变化,评价丹参酮ⅡA磺酸钠的临床疗效。方法选取79例心绞痛患者作为心绞痛组,另将同期经冠脉造影排除冠心病的患者55例作为对照组,比较2组患者血清CRP、UA、血脂、胆红素水平。将心绞痛患者随机分为2组,分别采用常规方法(常规治疗组)及加用丹参酮ⅡA磺酸钠(丹参酮组)治疗,比较2组患者临床疗效。结果与对照组比较,心绞痛组患者CRP、UA、低密度脂蛋白、总胆红素水平显著增高,高密度脂蛋白水平显著降低。丹参酮组患者显效率明显高于常规治疗组,治疗后丹参酮组患者UA、总胆固醇、甘油三酯水平均显著低于常规治疗组。结论血清CRP、UA、血脂、胆红素可能在心绞痛发病过程中起到重要作用,丹参酮ⅡA磺酸钠是治疗心绞痛有效药物。
Objective To observe the levels with angina, and to analyze the therapeutic effect of of CRP, UA, lipids and bilirubin of patients tanshinone ⅡA sulfonate. Methods Seventynine patients with angina were selected as angina group, and 55 patients without coronary heart disease confirmed by coronary angiography were randomly selected as control group. The levels of CRP, UA, lipids and bilirubin in the two groups were compared. The angina patients were divided into two groups randomly and received routine therapy （routine group） and tanshinone ⅡA sulfonate plus routine therapy （tanshinone group）, respectively. The clinical efficacies were compared. Results Compared with the control group, the levels of CRP, UA, LDL, TBIL in angina group increased obviously, while the level of HDL decreased obviously. The significant effective rate in tanshinone group was obviously higher than that in routine group, and the levels of UA, TC, TG in tanshinone group were obviously lower than that in routine group. Conclusion CPR, UA, lipids and bilirubin may play important roles in the pathogenesis of angina. Tanshinone ⅡA sulfonate has great effect on patients with angina.
出处
《实用临床医药杂志》
CAS
2012年第21期25-27,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220176)
