摘要
2012年的诺贝尔化学奖授予了美国科学家Robert J.Lefkowitz以及Brian K.Kobilka,以表彰他们在"G蛋白偶联受体"研究中作出的突出贡献。G蛋白偶联受体是人体中分布最广、地位最重要的膜蛋白受体,其著名的7次跨膜结构使得人人了解了其复杂性,同时,它所介导的各种信号通路也使得其有着重大的研究和临床价值。通过简单介绍G蛋白偶联受体的结构和功能方面的一些概况,来对其进行一些讨论。
The 2012 Nobel Prize in Chemistry has been awarded to American scientists Robert J. Lefkowitz and Brian K. Kobilka groundbreaking discoveries that reveal the inner workings of an important family of such receptors： G-protein-coupled receptors （GPCR）. The structure of GPCRs contains a seven-transmembrane domain, which pass through the cell membrane seven times. GPCRs are involved in a variety of physiological processes by sensing the ligand outside the cell and activating the downstream signal transduction pathway inside the cell. This review will summarize the structure and function of GPCRs and discuss their application in the treatment of human diseases and clinical medicine.
出处
《生命科学》
CSCD
2012年第12期1373-1379,共7页
Chinese Bulletin of Life Sciences
基金
国家重大科学研究计划("973项目")(2011-CB966304
上海浦江人才计划(11PJ1410600)
关键词
G蛋白偶联受体
G蛋白
7次穿膜结构受体
G protein-coupled receptor
G protein
seven-transmembrane domain receptor
7TM receptor
