摘要
原子转移自由基聚合(ATRP)是一种新颖的信号放大方法。在聚合过程中,成百上千个单体分子聚集形成长链聚合物,聚合物的侧链可以修饰丰富的功能基团,可与电化学或光学活性物质发生键合反应,从而显著增加单元生物分子识别反应信号分子的负载量,提高了检测灵敏度,实现了生物分子检测的信号放大。本文综述了ATRP的反应机理及其近年来在生物传感中的应用,并展望了其发展前景。
Atom transfer radical polymerization（ATRP） is a new class of signal amplification method.The polymer growth results in local accumulation of monomers to form long-chain polymers.The growth of long chain polymeric materials provides excess active groups for electroactive or photoactive molecules coupling,which in turn significantly increases the loading of signal molecules and enhanced detection sensitivity.This review introduced the mechanism of ATRP,summarized the recent application of ATRP in biosensing.Particularly,future study and prospect were envisioned.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2012年第12期1797-1802,共6页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金资助项目(No.20875013)
