摘要
目的瘦素(leptin)及其受体与肥胖密切相关,而肥胖是患甲状腺癌的高危险因素之一。目前瘦素与甲状腺癌的相关性研究较少。本实验将重点探讨瘦素受体(OBR)在甲状腺癌中的表达与临床特征的关系。方法利用免疫组织化学检测76例甲状腺乳头状癌组织(其中26例发生淋巴结转移,50例未发生淋巴结转移)和16例甲状腺腺瘤组织中瘦素受体的表达情况。结果 OBR在甲状腺乳头状癌的阳性表达率(73.68%)与在甲状腺腺瘤的阳性表达率(43.75%)比较有显著性差异(P<0.05)。在甲状腺乳头状癌中,56例阳性表达组的肿块直径大小(2.37±1)cm与20例阴性表达组的肿块直径大小(1.5±1)cm比较有明显差异,差别有统计学意义(P<0.01)。OBR表达与年龄、术前体重、绝经情况、淋巴结转移、多发性等因素无统计学意义(P>0.05)。结论 OBR的表达与甲状腺乳头状大小有关,可能参与肿瘤细胞的增殖、生长。
Objective Leptin and its receptor are closed correlation with obesity,and obesity is one of high risk factors in papillary thyroid carcinoma.But there is no obviously evidence that how leptin works in papillary thyroid carcinoma.So our study＇s purpose is that expression and clinical correlation studies of Leptin receptor in papillary thyroid carcinoma.Methods The expression of obr was detected by immunohistochemistry（IHC）with sreptavidin-peroxidase（SP）in 76 PTC tissues（26 with lymph node metastases,50 without lymph node metastases）and 16 thyroid adenoma tissues.Results The rates of positive expression obr were 73.68%（56/76）and 43.75%（7/16）in papillary thyroid carcinoma and thyroid adenoma tissues.The difference between the two groups was significant（P0.05）.In papillary thyroid carcinoma tissues,the tumor size of the positive expression group（2.37±1cm）was obviously different with the negative expression group.The difference was significant（P0.01）.And the expression of obr was not significant related to age,preoperative body weight,menostasis,lymph node metastases and mulifocality.Conclusion The expression of leptin receptor is associated with tumor size.Maybe leptin and its receptor participate in propagation and growth of the tumor cells.
出处
《济宁医学院学报》
2012年第6期402-404,共3页
Journal of Jining Medical University
基金
山东省自然科学基金(ZR2009CM070)
济宁市科技发展计划(2011-31)
济宁医学院青年基金(JYQ2011KM006)资助
关键词
乳头状甲状腺癌
瘦素受体
免疫组化
增殖
Papillary thyroid carcinoma
Leptin receptor
Immunohistochemistry
Propagation
