摘要
目的 :通过辛伐他汀及其与维生素E联用治疗冠心病合并低高密度脂蛋白 -胆固醇 (HDL -C)血症患者 ,探讨HDL -C与氧化修饰低密度脂蛋白 (Ox -LDL)及血小板活化的关系。方法 :选择冠心病合并低HDL -C血症病人 40例 ,分为辛伐他汀组及辛伐他汀与维生素E联合治疗组 ,比较治疗前后Ox -LDL、血栓素B2 (TXB2 )、血小板膜表面α -颗粒膜蛋白 (GMP - 140 )水平的变化及与HDL -C的关系。结果 :两组血浆HDL -C浓度均较治疗前明显升高 ,接近正常对照水平。联合治疗组血浆Ox -LDL、TXB2 浓度、GMP - 140水平均较治疗前明显降低。辛伐他汀组上述 3指标 (不包含HDL -C)亦较治疗前明显降低。结论 :在体内HDL -C亦能有效抑制LDL的氧化修饰 ,联合使用辛伐他汀与维生素E提高HDL -C ,降低Ox -LDL浓度后 ,能有效抑制血小板活化。
AIM: Using simvastatin and vitamine E (Vit-E) treatment to coronary artery disease (CAD) patients with low HDL, to investigate the relationship between Ox-LDL, platelet activation and HDL. METHODS: 40 CAD patients with low HDL were divided into two groups (A and B): A group oral simvastatin, B group oral simvastatin and Vit-E. The level of serum Ox-LDL, TXB 2 and GMP-140 were measured before and after treatment. The relationship between Ox-LDL, TXB 2, GMP-140 and HDL were analysed. RESULTS:The level of serum HDL was significantly increased in A and B group after treatment and attained normal level. The level of serum Ox-LDL, TXB 2 and GMP-140 were decreased significantly after simvastatin and Vit-E treatment and neared normal. CONCLUSIONS:This study confirmed that HDL can effectively refrain LDL oxidation. It also revealed that Vit-E and simvastatin treatment were more effectively refrained platelet activation by increasement of HDL and decreasement of Ox-LDL.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第6期495-497,共3页
Chinese Journal of Pathophysiology
基金
山西省青年科学基金资助 (9710 2 8)
