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基质金属蛋白酶MMP-2、MMP-9含量表达与大肠癌浸润转移相关性研究 被引量:4

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摘要 目的:观察大肠癌患者血清中基质金属蛋白酶(MMPS)含量与肿瘤侵袭和转移的关系,旨在为大肠癌的诊断和治疗提供依据。方法:应用酶联免疫吸附试验双抗体夹心法检测大肠癌患者血清中MMP-2、MMP-9含量变化。结果:大肠癌转移组,大肠癌非转移组,分别与正常对照组相比,差异均显著,且与病理分级和临床分期成正相关。结论:MMPS含量动态检测可作为评估大肠癌预后的客观指标。
作者 姚路明
出处 《吉林医学》 CAS 2012年第34期7461-7462,共2页 Jilin Medical Journal
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参考文献6

  • 1刘海义(综述),梁小波(审校).早期直肠癌的治疗进展[J].国际肿瘤学杂志,2010,37(9):700-703. 被引量:4
  • 2Langenskiold M,Holmdahl L,Falk P,et al.Increased plas-ma MMP-2protein expression in lymph node-positive patients with colorectal cancer[J].Int J Colorectal Dis,2005,203:245.
  • 3Nagase H,Visse R,Murphy G.Stuucture and function of matrix metallo-proteinases and TIMPs[J].Cardiovasc Ris,2006,69(3):562.
  • 4Cho YB,Lee WY,Song SY,et al.Matrix metalloproteinase-9activity is associated with poor prognosis in T3-T4node-negative colorectal cancer[J].Hum Pathol,2007,38(11):1603.
  • 5Tutton MG,George ML,Eccles SA,et al.Use of plasma MMP-2and MMP-9levels as a surrogate for tumour expression in colorectal cancer patients[J].Int J Cancer,2003,107(4):541.
  • 6邱炜(综述),周钢桥,贺福初(审校).金属蛋白酶类组织抑制剂及其基因多态性与肿瘤[J].国际肿瘤学杂志,2007,34(10):738-740. 被引量:1

二级参考文献26

  • 1Overexpression of TIMP-1 mediated by recombinant adenovirus in hepatocellular carcinoma cells inhibits proliferation and invasion in vitro[J].Hepatobiliary & Pancreatic Diseases International,2006,5(3):409-415. 被引量:6
  • 2Seakwoo Lee,Kevin K Desai,Kenneth A Iczkowski,Robert G Newcomer,Kevin J WU,Yun-Ge Zhao,Winston W Tan,Mark D Roycik,Qing-Xiang Amy Sang.Coordinated peak expression of MMP-26 and TIMP-4 in preinvasive human prostate tumor[J].Cell Research,2006,16(9):750-758. 被引量:18
  • 3Nash GM,Weiser MR,Guillem JG,et al.Long-term survival after transanal excision of T1 rectal cancer.Dis Colon Rectum,2009,52(4):577-582.
  • 4Nastro P,Beral D,Hartley J,et al.Local excision of rectal cancer:review of literature.Dig Surg,2005,22(1-2):6-15.
  • 5You YN,Baxter NN,Stewart A,et al.Is the increasing rate of local excision for stage 1rectal cancer in the United States justified? A nationwide cohort study from the National Cancer Database.Ann Surg,2007,245(5):726-733.
  • 6Folkesson J,Johansson R,P(a)hlman L,et al.Population-based study of local surgery for rectal cancer.Br J Surg,2007,94 (11):1421-1426.
  • 7Maclbouly KM,Remzi FH,Erkek BA,et al.Recurrence after transanal excision of T1 rectal cancer:should we be concerned? Dis Colon Rectum,2005,48(4):711-719.
  • 8Fang WL,Chang SC,Lin JK,et al.Metastatic potential in T1 and T2 colorectal cancer.Hepatogastroenterology,2005,52(66):1688-1691.
  • 9Rasheed S,Bowley DM,Aziz O,et al.Can depth of tumour invasion predict lymph node positivity in patients undergoing resection for early rectal cancer? A comparative study between T1 and T2 cancers.Colorectal Dis,2008,10(3):231-238.
  • 10Steele GD Jr,Herndon JE,Bleday R,et al.Sphincter-sparing treatment for distal rectal adenocarcinoma.Ann Surg Oncol,1999,6(5):433-441.

共引文献3

同被引文献45

  • 1郝凤进,张勇.CD147与MMP-9蛋白在大肠癌中的表达[J].中国医科大学学报,2009,38(5):321-323. 被引量:4
  • 2贺兼斌,张平,王小华,欧立文,龙治峰.槲皮素联合苏拉明对肺腺癌小鼠移植瘤生长的抑制作用[J].肿瘤,2006,26(4):322-326. 被引量:8
  • 3韩成敏,陈鑫,吴东辉.基质金属蛋白酶MMP-2、MMP-9表达同舌癌侵袭和转移相关性研究[J].吉林医学,2006,27(5):476-477. 被引量:2
  • 4许元鸿,欧阳兵,于国志,郭仁宣,郭克建.PTEN、P16表达与原发性胆囊癌病理生物学行为及预后的关系[J].世界华人消化杂志,2007,15(11):1314-1317. 被引量:5
  • 5Langenskiold M, Holmdahl L, Falk P, et al. Increased plasma MMP-2 protein expression in lymph node-positive patients with colorectal cancer[J]. Int J Colorectal Dis,2005,203: 245.
  • 6Yee SC,Jong GK,Sang KS,et al.Association of vascular endothelial growth factor gene polymorphisms with susceptibilityand clinicopathologic characteristics of colorectal cancer[J].J Korean Med Sci,2008,23(3):421-427.
  • 7李延林,耿长辉,刘钺,等.MMP-7蛋白表达及微血管密度与大肠癌浸润和微转移的相关性研究[J].心理医生,2012,18(5):89-90.
  • 8黄婉,陈志南.CD147分子N-糖基化修饰的功能研究及其在肿瘤进展中的意义[D].西安:第四军医大学,2012.
  • 9lllemann M,Bird N,Majeed A,et al.MMP-9 is differentially expressed in primary human colorectal adenocarcinomas and their metastases[J].Mol Cancer Res,2006,4(5):293-302.
  • 10Meneses-Garcia A,Betancourt AM,Abarca JH,et al.Expression of the metalloproteases MMP-1,MMP-2,MMP-3,MMP-9,MMP-11,TIMP-1 and TIMP-2 in angiocentric midfacial lymphomas[J].World J Surg Oncol,2008,27(6):114.

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