摘要
目的：观察阿斯匹林、抵克力得、法安明预防冠状动脉支架亚急性血栓形成的效果。方法：在37例冠心病人成功植入43个支架。男31例，女6例，平均53岁。术前至少二天口服阿斯匹林300mg，一日一次；抵克力得250mg，一日一次。穿刺动脉成功后注射肝素10 000U，术中每延时1小时追加肝素3 000U。术毕4小时退出动脉鞘，1小时后开始皮下注射法安明10 000IU，一日一次，共7～14天。术后仍口服阿斯匹林、抵克力得，二者剂量同术前。结果：2周期间，所有病人均无胸痛加重，ECG缺血性改变均改善，硝酸甘油耗量明显降低。无冠脉支架亚急性血栓形成及出血并发症。结论：联合应用阿斯匹、抵克力得、法安明预防冠脉支架亚急性血栓形成安全、有效。
Objective: To observe the efficacy of combination of aspirin, ticlid and fragmin in the prevention of subacute stent thrombosis. Methods Percautaneous implanation of 43 coronary stents were perfom ed in 37 patients(31 males and 6 females with an average of 53 years) with coron ary heart disease, Oral aspirin(300mg QD) and ticlid(250mg QD) were given at least two days before operation After successful puncture of the femoral artery, of 10 000 U heparin was injected and another 3 000U heparin would be given if the operation prolonged for another hour. Pulling out the artery sheath four hours after the operation completed and hypodermic injection of fragmin(10 000U QD) was given once a day for 7～14 days. Aspirin and ticlid were given as former dosage.Results: In this series ,chest pain relieved ,ischemic ECG changes were improved, and the am ount of consumption of nitrates was dramatically decreased, and no subacute stent thrombosis or bleeding occured. Conclusion: Combination of aspirin, ticlid and fragmin may be safe and effective in the prevention of subacute stent thrombosis.
出处
《农垦医学》
2000年第1期6-8,共3页
Journal of Nongken Medicine
