摘要
了解前列腺素E1(PGE1)对原发性肺动脉高压的治疗效果。方法 :13例原发性肺动脉高压 (男6女 7)每日PGE110 0～ 2 0 0 μg ,以 15ng·kg-1·min-1起 ,每天追加 5ng·kg-1·min-1共 4d ,致 30ng·kg-1·min-1止 ,静脉输注。血压、心率及Swan Ganz导管血液动力学、心输出监测。结果 :PGE1明显减低体肺循环阻力及肺动脉压力 ,在一定剂量范围内不影响血压 ,存在量效关系及时效关系。但基础肺动脉压力过高者大剂量静点PGE1可引起血压下降。结论 :PGE1可明显减低体肺循环阻力及肺动脉压力 ,对肺动脉有相对选择性 ,但用量应个体化并监测血压 ,一般以 2 5ng·kg-1·min-1剂量最佳。连续用药时停药后疗效并不很快消失。
Objective:This clinical study was performed in order to evaluate the effects of prostaglandin E 1 (PGE 1) on primary pulmonary hypertension. Methods:13 patients with primary pulmonary hypertension were observed by using Swan Ganze catheter. Then the effects of PGE 1 (15～30 ng·kg -1 ·min -1 ) on hemodynamics were observed day by day for 4 days. Results:PGE 1 (15～30 ng·kg -1 ·min -1 VD) not only decreases pulmonary pressure and resistance, increses cardiac output and decreases systemic resistance, but also have no effects on systemic pressure in some optimal ranges. But systemic BP of 3 patients whose PAPs were more than 10.67 kPa at rest before PGE 1 treatment declines (BPS<12kPa) after using PGE 1 40, 50, 80 ng·kg -1 ·min -1 for 15 to 30 minutes respectively. Conclusion:PGE 1 could decline pulmonary and systemic resistance and pulmonary pressure apparently, with relative selectivity to pulmonary artery. But it should be used individually and the blood pressure should be monitored.
出处
《军医进修学院学报》
CAS
2000年第2期151-154,共4页
Academic Journal of Pla Postgraduate Medical School
关键词
前列腺素E1
肺动脉高压
血流动力学
药物疗法
prostaglandin E 1 (PGE 1、alprostadil、u 10136)
pulmonary hypertension
primary
treatment
hemodynamics
