摘要
目的:观察地佐辛抑制阑尾手术牵拉反射的效果。方法:选择阑尾切除术患者40例,随机数字法分成地佐辛组(A组)和芬太尼+咪唑安定组(B组),每组20例,行双盲试验,于术前分别静脉给予地佐辛5 mg和芬太尼0.05 mg+咪唑安定2.5 mg,记录患者麻醉前(T1)、手术开始15 min(T2)、牵拉阑尾时(T3)的平均动脉压(MAP)、心率(HR)、警觉/镇静评分(OAA/S),并观察术中恶心呕吐、呼吸抑制、躁动、循环系统异常等不良反应。结果:在T2、T3时点A组的MAP、HR明显高于B组(P<0.05),OAA/S评分两组无差异,但用药前后组内比较明显降低(P<0.05),总不良反应发生例次A组明显低于B组(P<0.05)。结论:地佐辛能有效抑制阑尾手术的牵拉反射,循环稳定,无明显不良反应。
Objective: To compare the effect of dezocine and fentanyl to attenuate the visceral reflex during appendectomy with intraspinal anesthesia.Methods: Forty patients undergoing appendectomy were equally randomized to divided into the groups of dezocine(A)and fentanyl with midazolam(B).Before incision A group was injected dezocine 5 mg and B group was injected fentanyl 0.05 mg combined with midazolam 2.5 mg.The MAP and HR and observer's assessment of alertness/sedation scale(OAA/S) were recorded before intraspinal anesthesia(T1),when operation begin(T2),when drag appendix(T3).The incidences of nausea,vomiting and restlessness were observed and the changes of circulation and respiration were also measured.Results: The MAP and HR was significantly higher in group A than that in group B at T2,T3(P<0.05).OAA/S scale degraded in different degree and significantly decreased at T2,T3(P<0.05),but there was no significant difference between the two groups(P>0.05).The incidences of adverse effect were obviously lower in group A than that in group B(P<0.05).Conclusion: Dezocine combined intraspinal anesthesia could attenuate the visceral reflex,which is better than fentanyl for this purpose.
出处
《现代医学》
2012年第6期654-656,共3页
Modern Medical Journal
