摘要
目的探讨降钙素原(PCT)与N末端B型利钠肽原(NT-proBNP)在老年严重脓毒症和脓毒性休克患者的病情和预后评估中的作用。方法选择我院住院治疗的老年严重脓毒症和脓毒性休克患者96例,入院后予PCT、NT-proBNP和心脏超声等检查,并予急性生理学及慢性健康状况评分系统(APACHEⅡ)评分。比较死亡组和存活组、严重脓毒症组和脓毒性休克组PCT、NT-proBNP和APACHEⅡ评分,分析NT-proBNP与左室射血分数(LVEF)的相关性。结果死亡组PCT、NT-proBNP和APACHEⅡ评分均大于存活组,差异有统计学意义(P<0.05);严重脓毒症组PCT、NT-proBNP和APACHEⅡ评分均小于脓毒性休克组,差异有统计学意义(P<0.05),NT-proBNP与LVEF呈负相关(r=-0.64,P<0.05)。结论 PCT和NT-proBNP能有效评估老年严重脓毒症和脓毒性休克的预后和病情,PCT和NT-proBNP升高提示预后不良。
Objective To explore the evaluation function of procalcitonin（PCT） and amino-terminal portion of brain natriuretic peptide（NT-proBNP） in elderly patients with severe sepsis and septic shock.Methods 96 elderly patients with severe sepsis and septic shock in our hospital were examined by PCT,NT-proBNP and cardiac ultrasound after admission,and were scored by APACHE Ⅱ.The PCT,NT-proBNP and APACHE Ⅱ scores were compared between the death group and the survival group,and between the severe sepsis group and septic shock group;The content of NT-proBNP and LVEF correlation was analyzed.Results The level of PCT,the level of NT-proBNP and APACHE Ⅱ scores in death group were significantly higher than those in survival group（P0.05）;The level of PCT,the level of NT-proBNP and APACHE Ⅱ scores in severe sepsis group were significantly lower than those in septic shock group（P0.05）,analysis of NT-proBNP and LVEF showed a negative correlation（r=-0.64,P0.05）.Conclusion The PCT and NT-proBNP levels have a certain prognostic evaluation function for elderly patients with severe sepsis and septic shock,and high levels of PCT and NT-proBNP might suggest a poor prognosis.
出处
《临床误诊误治》
2012年第12期47-50,共4页
Clinical Misdiagnosis & Mistherapy
关键词
降钙素原
N末端B型利钠肽原
脓毒症
脓毒性休克
预后
Procalcitonin
Amino-terminal portion of brain natriuretic peptide
Sepsis
Septic shock
Prognosis
