摘要
目的观察牛磺酸灌服6周后对压力超负荷大鼠心肌中钙调神经磷酸酶（CaN）和肾上腺髓质素（ADM）的影响。方法将Wistar大鼠随机分为3组：对照组、缩窄组和给药组。参照Anderson方法制作压力超负荷心肌肥厚大鼠模型。术后1周开始给予牛磺酸50mg·kg^-1·d^-1，给药6周后处死动物，检测左心系数（左室重／体重比，LVW／BW）、CaN活性及ADM含量。结果与对照组相比，缩窄组大鼠SBP、LVW／BW显著升高（P〈0．05），心肌中CaN活性、ADM含量显著增高（P〈O．05）。给药组与缩窄组相比，SBP、LVW／BW下降（P〈0．05），心肌中CaN活性、ADM含量显著下降（P〈0．05）。结论牛磺酸有降低压力超负荷大鼠收缩压及减轻心肌肥厚的作用，该作用可能与其抑制CaN活性和ADM分泌有关。
Objective To observe the influence of taurine to calcineurin （CaN） and adrenomedullin （ADM） in the myocardium of pressure overload rats which was treated with 6 weeks of taurine. Methods The Wistar rats were randomly divided into 3 groups： sham-operated group, partial-operated group, taurine-treated group. Referring to the Anderson method, manufacture the model of pressure overload rats, a week later, taurinetreated group was given taurine by 50 mg·kg^-1·d^-1. After been treated by six weeks, the systolic blood pressure （SBP） of big mouse was measured, left ventricu｜ar mess index （LVW/BW） was calculated, the activity of CaN and the level of AMD were measured. Results Comparing with sham-operates group, the SBP and LVW/BW of partial-treated groups were increased （P〈0.05）, the activity of CaN and the level AMD in cardiac muscle were increased （P〈0.05）. Comparing with partial-operated groups, SBP and LVW/BW of taurine-treated group were decreased （P〈0.05）, and the activity of CaN and the level AMD were decreased （P〈0.05）. Conclusion Taurine can decrease SBP and produce a good preventive effect on the pressure overload rats by decreasing the activity of CaN and the level of ADM.
出处
《中国心血管病研究》
CAS
2012年第12期944-946,共3页
Chinese Journal of Cardiovascular Research
