摘要
目的探讨影响小肠间质瘤预后的因素。方法回顾性分析2005年1月至2010年12月河南省肿瘤医院普外科手术治疗的41例小肠间质瘤患者的临床及随访资料，进行NIH恶性危险度分级，采用Kaplan．Meier法比较不同因素对生存率的影响，并用COX多因素回归分析对该组病例进行预后分析。结果本组41例小肠间质瘤患者位于十二指肠12例，空回肠29例，其中有消化道出血16例。有消化道出血史患者术后3年生存率为22％，而无出血史者为65％，两者相比差异有统计学意义（χ2=6．613，P=0．012）。COX多因素回归分析表明肿瘤原发部位、复发转移及消化道出血是小肠间质瘤预后的有效预测指标。结论消化道出血是小肠间质瘤最常见的临床症状，肿瘤原发部位、复发转移及消化道出血是影响小肠间质瘤预后的独立影响因素。
Objective To investigate the prognositic factors of small intestine stromal tumors after radical resection. Methods The elinicopathological data of 41 patients with small intestine stromal tumors admitted between January 2005 and December 2010 in Henan Tumor Hospital were analyzed restrospectively. Kaplan-Meier survival rate and COX regression were used to evaluate the prognostic factors. Results There were 22 males and 19 females. The age ranged from 22 to 78 years old （median,55years）. Location of tumor included duodenum （n = 12） , jejunum and ileum （n = 29）. The 3-year survival rate was 22% in those 16 cases who reported preoperative gastrointestinal bleeding and 65% in those without GIT bleeding, the difference was statistically significant （P =0. 0012）. COX model showed that tumor size, the tumor location, recurrence and metastasis were independent risk factors associated with the prognosis in small intestine stromal patients （P 〈 0. 05 ）. Conclusions The most common clinical presentation of these tumors was gastrointestinal bleeding. The tumor location, recurrence and metastasis and gastrointestinal bleeding was indenendent risk factors associated with the prognosis of small intestine stromal tumor natients.
出处
《中华普通外科杂志》
CSCD
北大核心
2012年第12期970-973,共4页
Chinese Journal of General Surgery
关键词
胃肠道间质肿瘤
预后
回归分析
Gastrointestinal stromal tumors
Prognosis
Regression analysis
