摘要
目的制备胡芦巴胶改性材料,探讨其作用于盐酸小檗碱片剂时对其崩解的影响。方法分别制备胡芦巴胶及其与丙烯酸的共聚物超多孔水凝胶,压制不同含有量上述材料的盐酸小檗碱片并测定片剂崩解时间。结果采用胡芦巴胶时的崩解时间小于无崩解剂时的,差异有统计学意义(P<0.05),且崩解时间随着葫芦巴胶的剂量增加而增加。超多孔水凝胶作为崩解剂时的崩解时间小于单纯采用胡芦巴胶时的,差异有统计学意义(P<0.05)。结论胡芦巴胶可以减少片剂的崩解时间,但是效果随着用量增加而下降,胡芦巴胶与丙烯酸的共聚物超多孔水凝胶可以作为超级崩解剂,在制药业中具有推广意义。
Objective To study the influence of fenugreek gum and its modified materials on disintegration of hydrochloride berberine tablet. Methods To produce FGM and eopolymer of FGM with acrylic acid and measure the disintegration time of berberine bydrochloride tablet with different quality of the above materials. Results It showed that a little of FGM cut down the disintegration time of tablet（P 〈 0.05）, but excess of FGM delayed these processes. The disintegration time of superporous bydrogel hybrid was significantly lower than FGM（P 〈 0.05）. Conclusion FGM can reduce disintegration time of tablet, but excess of FGM delay these processes. Superporous hydrogel hybrid can be as a super disintegrant in the pharmaceutical industry to promote meaningful.
出处
《中国医药科学》
2012年第24期53-54,共2页
China Medicine And Pharmacy
关键词
胡芦巴胶
共聚物
崩解
Fenugreek galactomannan
Copolymer
Disintegrant
