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大肠埃希菌外膜蛋白酶T毒力机制的研究进展 被引量：1

Progress on the virulence mechanism of outer membrane protease T from Escherichia coli
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摘要 大肠埃希菌是引发尿路感染的主要病原体。流行病学调查显示,外膜蛋白酶T(OmpT)与尿路感染中大肠埃希菌的毒力相关。本文就OmpT的底物专一性、对宿主阳离子抗菌肽的抵抗,以及在纤溶系统和菌株黏附侵袭中的作用等方面的研究进展进行综述。 Uropathogenic Escherichia coli （UPEC） is the major cause of urinary tract infections worldwide. Outer membrane protease T （OmpT）, as a putative uropathogenic virulence factor, is found more frequently in UPEC than in fecal isolates. This review covers the current progress on substrate specificity of OmpT, resistance to cationic antimicrobial peptides, roles in the fibrinolytic system and bacterial adhesion and invasion.
作者 惠长野 黄胜和 曹虹 张艳芳
机构地区 深圳市职业病防治院 南方医科大学
出处 《微生物与感染》 2012年第4期233-238,共6页 Journal of Microbes and Infections
基金 国家自然科学基金(30972637)
关键词 大肠埃希菌 外膜蛋白酶T 毒力 尿路感染 Escherichia coli Outer membrane protease T Virulence Urinary tract infection
分类号 R378 [医药卫生—病原生物学]
  • 相关文献

参考文献35

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共引文献10

同被引文献12

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微生物与感染
2012年 第4期

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