摘要
目的比较根治性放疗联合替吉奥与单纯根治性放疗治疗早期鼻咽癌的近期疗效和毒性反应.方法2009年1月1日至2010年1月1日,88例早期鼻咽癌患者,随机分为试验组和对照组,每组44例.对照组单一放疗,每周5次,每次2.0 Gy,放疗总剂量为60～66 Gy;试验组于放疗同时口服替吉奥胶囊,替吉奥初始剂量为65 mg/(m2.d),2次/d,周期为第1至第8天,间歇期为2周.结果 88例患者全部完成治疗,均评价为CR,有效率为100%.试验组和对照组2 a局部控制率分别为100%(44/44)和90.9%(40/44),2组相比差异有统计学意义(P<0.05).毒副作用主要为骨髓抑制、胃肠道反应.结论根治性放疗同时联合替吉奥治疗早期鼻咽癌局部控制率优于单纯放疗,远期疗效和毒性反应尚待进一步研究.
Objective To explore the curative effect and toxicity of radical radiation therapy combined with S-1 for early nasopharyngeal carcinoma.Methods From Jan.1st 2009 to Jan.1st 2010,88 cases of early early nasopharyngeal carcinoma were divided into two groups： the joint S-1 and radiotherapy group（experimental group） and the single radiotherapy group（control group）,and 44 cases in each group.Patients in the control group only received radiation therapy,they were adopted ordinary radiation therapies,five times a week,2.0 Gy each time,total dose was 60 ~ 66 Gy.Patients in the experimental group took S-1 capsules orally while receiving radiation therapy,the initial dose was 65 mg/（m.d）,bid,d1～d28 and the intermittent period was twoweeks.Results All of the 88 patients completed treatment,and were evaluated as CR,the effective rate was 100%.2-year local control rates were 100%（44 / 44）for experimental group and 90.9%（40/44）for control group,there was significant difference（P〈0.05）between two groups.The main side effects were myelosuppression and gastrointestinal reactions.Conclusions Radiation therapy combined with S-1 get higher local control ratio than single radiation therapy.But the long-term outcomes and toxicities need to be further investgated.
出处
《昆明医科大学学报》
CAS
2012年第10期93-96,共4页
Journal of Kunming Medical University
关键词
鼻咽癌
替吉奥
根治性放疗
Nasopharyngeal carcinoma
S-1
Radical radiation therapy
