摘要
目的 探讨异丙酚对老年及成年大鼠血脑屏障通透性的影响。方法 用依文氏蓝染色及光镜、电镜方法 ,观察老年及成年大鼠静脉恒速分别输入高浓度和低浓度异丙酚后 ,其血脑屏障通透性和脑形态结构的变化。结果 (1)输入高浓底和低浓度异丙酚 1h对老年及成年大鼠血脑屏障通透性无影响 ;(2 )HE染色光镜观察各组脑结构均正常 ;(3)电镜下见各组的镧离子均在血管腔内 ,脑组织结构正常。结论 能引起脑电图爆发抑制且循环改变不大剂量的异丙酚 。
Objective To evaluate the influence of propofol on the permeability of the blood brain barrier(BBB) in adult and aged rats.Methods Aged or adult rats were given two doses propofol in 1 hour,respectively.BBB permeability was examined by optical microscopy,electromicroscopy and Evans blue(EB) staining.Results (1)Brain EB staining was not seen in aged or adult groups that at either dose of propofol.(2)In all groups of aged and adult rats,the structure of the blood vessels was normal and lanthanum was not seen outside the blood vessels.(3)There were no significant changes in the central nervous system under microscope or electromicroscope in any groups.Conclusions Propofol at the two doses has no significant effect on BBB permeability or on the central nervous system morphology in aged and adult rats.
出处
《中华麻醉学杂志》
CAS
CSCD
北大核心
2000年第3期169-171,共3页
Chinese Journal of Anesthesiology
