摘要
目的探讨血浆D-二聚体在肝硬化食管静脉曲张及其氩离子凝固术治疗患者中的变化。方法运用ELISA双抗体夹心法分别对发生食管静脉曲张(B组)和未发生食管静脉曲张(A组)的肝硬化患者,以及应用氩气刀行内镜下氩离子凝固术序贯治疗出现上消化道出血的肝硬化患者(C组)的血浆D-二聚体进行测定。结果 A、B、C3组肝硬化患者血浆D-二聚体浓度[(385±1.7)mg/L、(515±1.8)mg/L、(801±1.5)mg/L]较正常参考值均升高(P均<0.05),且发生上消化道出血者(C组)高于有或无食管静脉曲张者(B、A组)(P均<0.05),有食管静脉曲张者高于无食管静脉者但差异无统计学意义(P>0.05);氩离子凝固术序贯治疗后肝硬化患者的血浆D-二聚体浓度[(1209±1.2)mg/L〗较本组治疗前明显升高(P均<0.05),但术后1个月明显下降[(582±1.1)mg/L],接近未发生过上消化道出血的肝硬化2组患者的血浆D-二聚体浓度(P>0.05)。结论血浆D-二聚体测定对预测食管静脉曲张出血有一定意义,其水平的动态变化可用于氩气刀凝固术效果的评估。
Objective To study plasma D-dimer changes of esophageal varices and argon plasma coagulation technique sequential treatment in patients with liver cirrhosis.Methods The concentrations of plasma D-dimer in liver cirrhosis patients with or without esophageal varices（group B and A） as well as before and after argon plasma coagulation for treating upper gastrointestinal bleeding of esophageal varices（group C）were detected and followed up.The concentrations of D-dimer were detected by double antibody sandwich ELISA-test.Results The plasma D-dimer concentrations in group A,B and C increased in turn [（385±1.7）mg/L,515±1.8）mg/L,（801±1.5）mg/L],and the differences among three groups wre not statistically significant（P0.05）.After argon plasma coagulation technique sequential treatment,the concentration of D-dimer obviously increased [（1 209±1.2） mg/L,P0.05],but it significantly decreased to the levels nearly similar with group A and B one month late [（582±1.1）mg/L,P0.05].Conclusions Plasma D-dimer level has a predictive role for upper gastrointestinal bleeding in patients with esophageal varices
出处
《中国临床研究》
CAS
2012年第12期1171-1172,共2页
Chinese Journal of Clinical Research
