摘要
目的 研究胃癌组织中DNA拓扑异构酶 (topoisomerase ,TopoⅡ ) ,谷胱甘肽S 转移酶 ( glutathioneS transferases ,GST π)和P 糖蛋白 (P glycoprotein ,P gp)表达的意义。 方法 应用免疫组织化学S P法对 98例胃癌进行检测。结果 在 98例胃癌中 ,74例 ( 75 .5 %)GST π表达阳性 ,5 6例 ( 5 7.1%)P 糖蛋白表达阳性 ,TopoⅡ计数 (TopoⅡLI)为 11.1%～ 3 8.2 %。三者均与胃癌的分化程度有关 (P <0 .0 5 ) ,而与患者的年龄、性别、肿瘤的大小、部位、浸润程度和淋巴结转移情况无关。结论 联合检测TopoⅡ ,GST π和P gp对胃癌的治疗有一定的指导意义。
Objective To study the clinical significance of DNA topoisomerase,glutathione S transferases and P glycoprotein expression in gastric carcinoma tissue.Methods The expression of DNA topoisomerase,glutathione S transferases and P glycoprotein in 98 cases of gastric carcinoma was studied with S P immunohistochemical technique.Results The DNA topoisomerase labeling index(TopoⅡ LI) was between 11.1% and 38.2% in 98 cases of gastric carcinoma.Positive expression of glutathione S transferases was 75.5% and positive expression of P glycoprotein was 57.1%.A significant correlation was found between the three figures and differentiated degree( P <0.05).The expressions of topoisomerase,glutathione S transferases and P glycoprotein were not found to correlate with patient′s age,sex,tumor size,location,invased layers,lymph node metastases.Conclusion The determination of topoisomerase,glutathione S transferases and P glycoprotein may be useful for the treatment of gastric carcinoma.
出处
《实用癌症杂志》
2000年第2期148-150,共3页
The Practical Journal of Cancer
关键词
胃肿瘤
DN-1拓扑异构梅
P-糖蛋白
GST
Gastric neoplasm
DNA topoisomerase(TopoⅡ)
Glutathione S transferases
P glycoprotein
