摘要
目的了解抗磷脂抗体（APA），抗活化的蛋白C（APCR）与抗磷脂血栓综合征（APL-T）的关系，进一步探讨APL-T血栓发生机制。方法以ELISA检测ACA（IgG，IgM，IgA）；APTT检测LA；APTT＋／－APC检测APCR。结果20例患者符合APL-T诊断。根据病因分类，100例SLE患者中14例为继发性APL-T；16例“原因不明”血栓与习惯性流产患者中6例为原发性APL-T。根据抗体分类，20例患者中12例LA阳性为狼疮抗凝因子血栓综合征（LA-T）；20例患者中12例ACA阳性为抗心磷脂抗体血栓综合征（ACA－T）。根据临床症状分类，20例患者中7例静脉血栓为Ⅰ型APL-T；3例脑梗死为Ⅱ型APL-T；1例静脉血栓合并脑梗死，习惯性流产为Ⅳ型（混合型）APL-T；9例习惯性流产为V型APL-T。ACA，LA与APL-T相关；APCR与APL-T密切相关。结论APA、LA引起获得性APCR可能是APL-T血栓的重要原因。
Objective To explore the cormlation between antiphospholipid antibodies (APA) activated pro-tein C resistance (APCR) and antiphospholipid thrombosis (APL-T) syndrome and investigate the mechanism ofthrombosis in APL-T syndrome. Methods ELISA, APTT-LA and APTT + / - APC methods were used to detectanticardiolipin antibodies (ACA), lupus anticoagulants(LA) and APCR in 20 APL-T syndrome patients respective-ly. Results Twenty patients were diagnosed as APL-T. The patients were classified in three ways. According toetiology, 14 of 100 systemic lupus erythematosus (SLE) patients were diagnosed as 'secondary' APL-T, and 6 of16 'unexplained' thrombosis and spontaneous abortion as 'Primary' APL-T syndrome. According to antibodies, 12of 20 patients with positive LA were diagnosed as lupus anticoagulant thrombosis syndrome (LA-T),12 of 20 pa-tients with positive ACA as anticardiolipin antibodies thrombosis syndrome (ACA-T). According to clinical presenta-tion: 7 of 20 patients with deep vein thrombosis were classified as type Ⅰ APL-T, 3 of 20 patients with cerebrovas-cular thrombosis as type Ⅱ, l of 20 patients with vein cerebrovascular thrombosis and spontaneous abortion as typeⅣ (mixing), and 9 of 20 patients with spontaneous abortion as type Ⅴ (fetal wastage type). The ACAs and LA arestrongly associated with APL-T. There is close relationship between APCR and APLT. Conclusion The acquiredAPCR might be an important reason for thrombosis in APL-T caused by APA and LA.
出处
《中华血液学杂志》
CAS
CSCD
北大核心
2000年第3期122-124,共3页
Chinese Journal of Hematology
基金
安徽省自然科学基金!98452234
关键词
抗磷脂综合征
抗活化的蛋白C
APCR
Antibodies, antiphospholipid
Thrombosis (APL-T) syndrome
Proteins
