摘要
目的对比安氟醚、七氟醚两种吸入麻醉药在腹部手术麻醉期间对机体耗氧量（ＶＯ２）的影响。方法选择择期腹部手术病人４０例，ＡＳＡⅠ～Ⅱ级，随机分为安氟醚（Ｅ）组和七氟醚（Ｓ）组。记录手术开始前、麻醉吸醚后５ｍｉｎ及手术开始后３０、６０、９０、１２０、１５０ｍｉｎ时的吸入一呼出氧浓度差（Ⅰ－ＥＤＯ２），分钟通气量（ＭＶ），计算ＶＯ２。同时记录呼气末ＣＯ２浓度（Ｅ－ＴＣＯ２），平均动脉压（ＭＡＰ），心率（ＨＲ），体温（Ｔ），最低肺泡有效浓度（ＭＡＣ）等参数。结果①两组在麻醉手术期间各时段机体ＶＯ２均降低，与术前相比均有显著性差异（Ｐ＜０．０１），但两组间各时段降低的程度无显著性差异（Ｐ＞０．０５）；②随手术时间延长，两组机体ＶＯ２均逐渐升高，但仍低于术前基础状态（Ｐ＜０．０５），然而，在手术１２０ｍｉｎ之后ＶＯ２又有下降趋势。结论安氟醚和七氟醚均降低机体耗氧量，两药间无明显差异。但随手术时间延长，麻醉诱导药的作用逐渐消退，机体耗氧量在逐渐升高后又随手术操作刺激减弱而降低。
Objective To compare oxygen consumption (VO2) during enflurane anesthesia with sevoflurane. Methods Forty elective laparotomy patients were assigned into two groups randomly. Inspired and expired O2 and CO2 concentration and minute ventilation were measured at different time to calculate VO2. Results ①Oxy gen consumption decreased after anesthesia. There were significant differences between pre-anesthesia and post anesthesia in the same group but no difference between two groups at any time; ②Oxygen consumption increased gradually as operation going on, then dropped after 2 hours. Conclusion Enflurane and sevoflurane decreased VO2. The VO2 increased gradually as operation going on, and then dropped since stress of operation weakened.
出处
《哈尔滨医科大学学报》
CAS
2000年第3期205-207,共3页
Journal of Harbin Medical University
关键词
耗氧量
安氟醚
七氟醚
腹部外科手术
oxygen consumption
enflurane
sevoflurane
stress reaction
abdominal surgery
