摘要
目的观察血浆置换（ＰＥ）控制肾移植术后排斥反应的疗效，并初步探讨其可能的作用机制。方法对肾移植前淋巴细胞毒试验阳性患者９例与术后出现排斥反应患者１０例１１例次行ＰＥ治疗，并于ＰＥ前后监测ｓＩＬ－２Ｒ、ＴＮＦ水平。结果９例移植前淋巴细胞毒试验阳性者ＰＥ后全部转阴雨顺利行肾移植手术，术后排斥反应低，只有１例次急性排斥反应。术后１１例次排斥反应ＰＥ后１０例次得到控制。ＰＥ后血清中ｓＩＬ－２Ｒ、ＴＮＦ水平较前下降。结论 ＰＥ配合常规药物疗法在预防和治疗肾移植术后排斥反应是有效的，其机制与ＰＥ下调ＴＮＦ、ｓＩＬ－２Ｒ水平有关。
Objective To observe a therapy of controlling the rejection of kidney post-transplantation-plasma exchange(PE), and explore its possible mechanism. Methods Nine patients of kidney pre-transplantation with positive lympho-toxicity test and 10 patients of kidney post-transplantation who appeared rejective, underwent PE and the levels of TNF, sIL-2R were measured before and after transplantation. Results Nine patients with positive lympho-toxicity before transplantation by PE became negative and the kidney operation were finished smoothly, its post-operation rejection was low except that there was a patient who appear acute rejective. Ten case times rejection of 11 which underwent PE were control. The level of plasma sIL-2R,TNF fell than before PE. Conclusion It is effective for PE with common drugs to prevent and post-transplantation rejection.
出处
《哈尔滨医科大学学报》
CAS
2000年第3期182-183,共2页
Journal of Harbin Medical University
关键词
血浆置换
肾移植
排斥反应
TNF
SIL-2R
plasma exchange
kidney transplantation
tumor necrosis factor
soluble interleukin-2 recepto
