摘要
目的 :探讨呕必亭预防高剂量顺铂腹腔热灌注所致恶心呕吐。方法 :57例患者接受DDP100mg/m2 +43℃生理盐水2500～3000ml腹腔灌注 ,腹灌第1周期用呕必亭或用对照药物胃复安 +地塞米松或恩丹西酮 ,第2周期交换应用。结果 :预防急性呕吐的有效率 ,呕必亭为88.9 % ,恩丹西酮为85.7% ,胃复安 +地塞米松为66.7 %(P<0.025)。其中完全缓解率为63.9 %、61.9 %、38.9 %(P<0.05) ,对慢性呕吐的预防(2～5天)的有效率分别为 :72.2 %～91.9 %、61.9%～90.4%、27.8 %～69.4 %(P<0.05)。结论 :呕必亭能有效地预防高剂量顺铂腹腔热灌注所致的呕吐 ,与恩丹西酮相仿 ,明显优于胃复安 +地塞米松 ,且给药方便。
Objective: To evaluate the effect of tropisetron in prevention of nausea and vomiting induced by peritoneal perfusion with heated large dose of cisplatin for G-I tract cancer patients with peritoneal metastases. Methods: Fifty-seven patients received peritoneal perfusion with heated cisplatin were randomly divided into two groups: Group A included 21 cases treated with tropisetron and ondansetron alternatively every week. Group B consisted of 36 cases, and 18 cases of them received tropisetron in the first week and then paspertin plus dexamethasone in the second week. Another 18 cases received the same drugs and vice versa. Results: The effective rate of tropisetron was 88.9%, ondansetron 85.7%, paspertin plus dexamethason 66.7% (P< 0.05), and the complete response rates were 63.9%, 61.9%, 38.9% respectively (P< 0.05). The effective rates for chronic vomiting (2～5 days) were 72.2～91.9%, 61.9～90.4%, 27.8～69.4% respectively (P< 0.05). Conclusion: Tropisetron can effectively prevent the vomiting induced by peritoneal perfusion with heated large dose of cisplatin as same as ondansetron, and it is superior to paspertinplus dexamethasone.
出处
《中国肿瘤临床》
CAS
CSCD
北大核心
2000年第6期446-448,共3页
Chinese Journal of Clinical Oncology
关键词
呕必亭
呕吐
顺铂
腹腔热灌注
肿瘤
Tropisetron Vomiting Cisplatin Heated peritoneal perfusion
