摘要
为探讨小剂量重组人生长激素（ｒｈＧＨ）对充血性心力衰竭患者心脏功能和结构的疗效。对２１例扩张型心肌病与缺血型心肌病心力衰竭患者随机分为传统治疗组（Ｃ组９例）和ｒｈＧＨ治疗组（ＧＨ组）１１例。所有病例均以洋地黄、利尿剂和硝酸酯治疗，ＧＨ组加用ｒｈＧＨ ４．５Ｕ，第 １个月隔日 １次，第 ２个月每周 ２次，第 ３个月每周１次。结果表明：治疗后两组患者的心功能，血液动力学指标和６ｍｉｎ步行试验（６’ＷＴ）时间均显著改善。与Ｃ组比较，ＧＨ组心功能分级（ＮＹＨＡ），舒张末左室内径（ＬＶＥＤ），和ＬＶＥＤ与左室壁厚度之比（Ｄ／Ｔ），以及肿瘤坏因子（ＴＮＦα）显著降低，而６’ＷＴ与心指数显著增高。
We designed a randomized, controlled study to evaluate the effect of low-dose recombinant human growth hormone(rhGH) on heart function and life quality of patients with congestive heart failure(CHF). 20 pa- tients with severe CHF due to dilated or ischemic cardiomyopathy (DCM/ICM ) were randomized into conventional therapy group(C, n=9), and rhGH group(GH, n=11). All patients were treated with digitalis,diuretics and nitro- vasodilators, and patients of GH received rhGH 4. 5in subcutaneously every other day for the first month, and then 2 doses weekly for the second month, and I dose weekly for the third month. After treatment, heart function, hemodynamics and 6-minute walking test(6'WT) were improved significantly both in GH and C. Comparing to C. Heart function class(NYHA),diastolic left ventricular internal dimension(LVED), and the ratio of LVED to left ventricular wall thickness(D/T) and plasma TNFQ reduced, while 6 'WT and cardiac index increased significantly in GH. Low-dose rhGH administered in stepwise reducing fashion for 3 months is favorable for the improvement of left ventricular size and function and life quality lin patients with CHF.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2000年第3期165-167,共3页
Medical Journal of Chinese People's Liberation Army
