摘要
目的 :用癌基因和抑癌基因蛋白产物在乳癌中过表达 ,探讨与病理分级 ,肿瘤生物学行为和预后指标雌激素受体 (ER)表达的关系 ,为临床治疗及预后的判断提供客观参数。方法 :应用免疫组化 S- P法检查 4 8例乳癌中 P53,C- erb B- 2 ,PCNA和 ER表达水平。结果 :4 8例乳癌中 P53,C- erb B-2 ,PCNA和 ER阳性表达率分别为 54% ,4 3% ,52 %和 4 1.6 %。P53,C- erb B- 2随着组织分级增高呈递增趋势 , 级与 、 级间阳性率差异显著 (P<0 .0 5) ,与 PCNA表达存在平行关系 ,与 ER表达呈负相关趋势 ;伴有淋巴结转移组与无淋巴结转移组间也存在显著差异 (P<0 .0 5)。结论 :P53,C- erb B- 2过表达与淋巴结转移及预后有密切关系 。
Objective:[WT5BZ]To assess the prognostic significance of over expression of P53,C erbB 2 in breast carcinomas [WT5HZ]Methods:[WT5BZ]In 48 cases of breast carcinoma the expression of P53,C erbB 2,PCNA and ER was studied using S P staining immunohistochemical technigues [WT5HZ]Results:[WT5BZ]The positive rate of P53,C erbB 2,PCNA and ER were 54%,43.7%,52%,41.6%.The resultpositive expression of P53,C erbB 2 were increased with the tisuess class.There were significant difference between Ⅰ and Ⅱ,Ⅲ(P<0.05),also between node positive and node negative patients(P<0.05).[WT5HZ]Conclusion:[WT5BZ]The over expression of P53,C erbB 2 may serve as a useful prognostic indicator in breast carcinomas [WT5HZ]
出处
《河北医学》
CAS
2000年第6期490-493,共4页
Hebei Medicine
