摘要
目的 观察大剂量激素吸入治疗慢性重度哮喘的临床疗效及副作用。方法 选择 38例重度哮喘患者随机分为A、B两组 ,分别给大剂量丙酸倍氯米松经储雾罐和不经储雾罐吸入治疗 8～ 14周。在治疗前后观察呼气峰流速 (PEF)和症状记分的改变及副作用的情况。结果 吸入大剂量激素可以显著改善患者的临床症状和气道阻塞。其主要不良反应为口腔霉菌感染、声音嘶哑或咽喉不适等局部副作用。用储雾罐吸入激素可以明显减少局部副作用的出现并增强疗效。
Objective To observe the therapeutic and adverse effects of large dosage of inhaled beclometasone on the patients with severe asthma. Methods Thirty eight patients with severe asthma were equally randomized into group A and group B. Large doses of beclometasone were inhaled with a spacer in group A and without a spacer in group B for 8 to 14 weeks. Peak expiratory flow (PEF), symptom scores and side effects were recorded before and after the treatment. Results Inhalation of large dose of beclometasone significantly ameliorated bronchial obstruction and other clinical symptoms. The major side effects of this therapy were fungus infection of the oral cavity, vocal hoarseness and laryngeal discomfort. Nevertheless all of the side effects could be alleviated with the usage of a spacer and the therapeutic effect of beclometasone was intensified at the same time. Conclusion Large dosage of inhaled beclometasone can alleviate the clinical manifestation and improve lung functions of the patients with severe asthma.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2000年第6期591-593,共3页
Journal of Third Military Medical University
