摘要
目的 探讨nm2 3蛋白及雌激素受体 (ER)的表达与大肠癌患者临床生物学行为及预后的关系。 方法 采用免疫组织化学方法 (LSAB) ,对 2 0 9例大肠癌标本分别进行nm2 3蛋白和ER的检测 ,并结合患者的临床资料进行分析。 结果 大肠癌组织nm2 3蛋白的表达水平与ER的表达水平呈明显正相关 (r=0 5 319,P <0 0 1)。nm2 3蛋白及ER的表达与患者年龄、性别、肿瘤部位、大体类型、组织类型、Dukes分期等无关 (r<0 4,P >0 0 5 ) ;用Cox回归模型进行多因素生存分析表明 ,大肠癌组织nm2 3蛋白及ER的表达水平与患者预后明显相关 (P <0 0 1) ,即nm2 3蛋白和 (或 )ER表达水平越高 ,患者预后越好。 结论 大肠癌nm2 3蛋白的异常表达与雌激素代谢紊乱有关 ,nm2 3蛋白和ER的检测有助于大肠癌患者的临床诊断及预后评估。
Abstract[WT5”BZ] To explore the relationship between clinicobiological action and expression of nm23 protein and estrogen receptor(ER) for colorectal cancer. [WT5”HZ]Methods[WT5”BZ] The expression of nm23 protein and ER for 209 cases of colorectal cancer was detected by immunohistochemistry assay(LSAB). [WT5”HZ]Results[WT5”BZ] The expression of nm23 protien was correlated with that of ER for colorectal cancer( r =0 5319, P <0 01). The expression of nm23 protein and ER in colorectal cancers was not related with patient′s age, sex, tumor position, pathological type, histological type, and Dukes stage ( r <0 4, P >0 05). The expression was related with the prognosis of colorectal cancer ( P <0 01). The higher the expression of nm23 protein and/or ER the better the prognosis, whereas the less the expression of nm23 protein and/or ER the worse the prognosis. [WT5”HZ]Conclusions[WT5”BZ] The abnormal expression of nm23 protein is correlated with the disturbance of estrogen metabolism in colorectal cancer. The detection of nm23 protein and ER is helpful for the diagnosis and prognostic evaluation of colorectal cancer. [WT5”HZ]
出处
《中华外科杂志》
CAS
CSCD
北大核心
2000年第7期514-516,共3页
Chinese Journal of Surgery
关键词
大肠肿瘤
NM23蛋白
雌激素受体
基因表达
Colorectal neoplasm
Genes, soppressor, tumor
Receptor, estrogen
Immunohistochemistry
Prognosis
