摘要
目的:综述乳腺癌前哨淋巴结(SLN)微转移研究进展和临床应用价值。方法:以"乳腺癌、前哨淋巴结、微转移"为关键词,检索PubMed、万方医学网和中国知网数据库2003-2012年发表的相关文献,共检索到中文文献40条,英文文献226条。纳入标准:1)乳腺癌SLN微转移的病例对照和前瞻性研究;2)SLN微转移检测方法的研究;3)SLN微转移的研究现况。根据纳入标准,共纳入分析30条文献。结果:腋淋巴结阴性的早期乳腺癌,前哨淋巴结活检(SLNB)可以替代腋淋巴结清除术(ALND)判断腋淋巴结状态。连续切片(SS)方法、IHC技术和分子分析技术均可以增加微转移的检出率。SLN微转移可能代表了渐进性的病情进展和非前哨淋巴结转移的高风险性。结论:SLN微转移的临床意义存在争论,随着SLNB技术的成熟,可以提高阳性淋巴结的检出率,进一步提高SLN的预测能力。
OBJECTIVE： To summarize research progress of sentinel lymph node （SLN） micrometastasis in breast cancer and clinical application value. METHODS： Literatures, published from 2003--2012, were searched in Medline and PubMed databases,with breast cancer, SLN and micrometastasis as key words. Totally 40 Chinese literatures and 226 English literatures were got. Inclusion criteria：Case control study and prespective study of SLN micrometastasis in breast cancer;Study about research assay of SLN micrometastasis;Research status of SLN micrometastasis. According to the criteria 30 literatures were involved. RESULTS： In early breast cancer with negative axillary nodes,the SLN biopsy（SL NB） can be used to replace axillary lymph node dissection（ALND） to determine the status of axillary nodes. The SLN mi- crometastasis can be detected with serial section, IHC technique, and molecule technique, besides the conventional patholo- gy assay. CONCLUSION：For SLN micrometastasis in patients with breast cancer prognosis should not be considered to be the same. SLN micrometastases may well represent a progressive disease progression and increased gradually in a SLN transfer risk.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2012年第19期1512-1515,共4页
Chinese Journal of Cancer Prevention and Treatment
